Edward Wilkinson, MD
Professor and Vice-Chairman
Director, Cytopathology Fellowship
Medical Director, Quantitative Pathology Laboratory, UFDRL
Adjunct Professor, Department of Obstetrics and Gynecology
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Dept. of Pathology, Immunology and Laboratory Medicine |
Currently Involved In:
Edward J. Wilkinson, MD is Professor and Vice Chairman in the Department of Pathology at the University of Florida College of Medicine, where he also directs the Cytopathology Fellowship program and is the Medical Director of the Department's Quantitative Pathology Laboratory. As prior president of the American Society for Colposcopy and Cervical Pathology he initiated the first Consensus Conference on the Management of Women with Abnormal Cervical Cytology in 2001, and served as the Chairman of the Steering Committee and Chair of the LSIL committee directing this evidence based conference. For the second 2006 ASCCP Consensus Conference he served on the Steering Committee and as Chairman of the Human Papillomavirus Testing Committee. Dr. Wilkinson is also a past President of the International Society for the Study of Vulvovaginal Disease and the Florida Society of Pathologists. He is Editor-in-Chief of the Journal of Lower Genital Tract Disease, and serves as a member of the editorial boards of the journals Human Pathology, International Journal of Gynecological Pathology, The Breast Journal, and The Journal of Gynecological Surgery. He also serves as a special reviewer for several other leading medical journals. He is listed in Who's Who in Medicine and Health, Who's Who in the World, and is in the Best Doctors in America,(gynecological pathology) being listed in the first, and all subsequent publications for the past 15 years. In a career spanning more than forty years, he has researched and published on cancers and pre-neoplastic lesions of the cervix, vulva, vagina, endometrium, ovary and breast. He has been awarded funding from the National Cancer Institute and the American Cancer Society, and served as a member of the Data and Safety Monitoring Committee of NCI's ALTS trial.
Notable scientific contributions include: first to directly measure and to quantitate alpha fetoprotein in ovarian endodermal sinus tumor. First to document, through retrospective sectioning and detailed analysis of 525 Stage 1 breast carcinoma cases initially interpreted as having negative lymph nodes, that occult micro metastasis can be detected and occur in over 15% of cases and that these micrometastaisis do not significantly decrease survival as compared to cases with negative lymph nodes. First to develop a mathematical model to estimate probabilities of missing micrometastasis in lymph nodes by histopathologic study when using various sectioning intervals. Pioneered in defining a subset of minimally invasive vulvar carcinomas as carrying essentially no risk for lymph node metastases. Instrumental in working with the ISSVD, the International Society of Gynecological Pathologists, and F.I.G.O. in establishing Stage IA vulvar carcinoma as a tumor stage, and a stage of tumor that can be managed by less than radical surgery. First to describe and define endometrial well differentiated papillary adenocarcinoma (subsequently called villo-glandular adenocarcinoma) and distinguish this tumor as having a relatively good prognosis as compared to papillary serous adenocarcinoma. First to report and document, with family linkage, congenital cirrhosis in the newborn due to S-Z phenotype alpha-1-antitrypisin deficiency. First to define and document acquired columnar cell metaplasia of the squamous mucosa of the vagina. Developed the first comprehensive etiologic classification of vulvar Paget disease based on histopathologic, immunohistochemical and clinical features. (See: E.J. Wilkinson in faculty in web site: www.pathology.ufl.edu)
Publications
- Wilkinson, EJ: Pap Smears and Screening for Cervical Neoplasia. Clin Obstet. and Gynecol 33:817, 1990.
- Wilkinson, EJ: The 1989 Presidential Address. International Society for the Study of Vulvar Disease. Terminology in Vulvar Disease. J Reprod Med 35:11, 981-991,1990.
- Khan, SR, Wilkinson, EJ: Bladder Stone in the Human Female: The Case of an Abnormally Located Intrauterine Contraceptive Device. Scanning Microscopy 4(2):395-398, 1990.
- Wolber, RA, Talerman, A, Wilkinson, EJ, Clement, PB: Vulvar Granular Cell Tumors with Pseudocarcinomatous Hyperplasia: A Comparative Analysis with Well-Differentiated Squamous Carcinoma. Int J Gynecol Pathol 10:59-66,1991.
- Wilkinson, EJ: Superficially Invasive Squamous Cell Carcinoma of the Cervix and Vulva: Distinctions in Staging and Diagnosis, Clinical Obstetrics and Gynecology 34:651, 1991.
- Wisniewski, PM, Wilkinson, EJ: Postpartum Vaginal Atrophy. American Journal of Obstetrics and Gynecology 165:1249-54, 1991.
- Wilkinson, EJ, Smith, LJ: Cervical Neoplasia, Its Association With Human Papillomavirus Infection. FL Med Assoc 80:106-11, 1993.
- Masood, S, Rhatigan, RM, Wilkinson, EJ, Barwick, KW, Wilson, WJ: Expression and Prognostic Significance of Estrogen and Progesterone Receptors in Adenocarcinoma of the Uterine Cervix. An Immunocytochemical Study. Cancer 72:511-18, 1993.
- Wilkinson, EJ, Guerrero, E, Daniel, R, Shah, K, Stone, IK, Hardt, NS, Friedrich, EG: Vulvar Vestibulitis is Rarely Associated with Human Papillomavirus Infection Types 6, 11, 16 or 18. Int J Gynecol Pathol 12(4):344-349, 1993.
- Hendricks, J, Hardt, N, Wilkinson, EJ, Pharis, P, Braylan, R: A method for detecting variability arising from errors in sample processing of paraffin-embedded tissue for DNA content analysis. Arch of Pathol Lab Med 117:1138-41, 1993.
- Hendricks, JB, Wilkinson, EJ, Pharis, PG, Sapi, Z, Braylan, RC: Quantitative Morphologic Assessment of Nuclei Extracted from Paraffin for DNA Flow Cytometry. Modern Pathology 6:565-9, 1993.
- Hendricks, JB, Wilkinson, EJ: Comparison of Two Antibodies for Evaluation of Estrogen Receptors in Paraffin-Embedded Tumors. Modern Pathology 6(6):765-70, 1993.
- Sapi, Z, Hendricks, JB, Pharis, PG, Wilkinson, EJ: Tissue section image analysis of breast neoplasms, evidence for false aneuploidy. Am J Clin Pathol 99(6):714-720, 1993.
- Wilkinson, EJ, Hendricks, JB: Fine Needle Aspiration of the Breast for Diagnosis of Preinvasive Neoplasia. J Cellular Biochemistry (JCB), Supplement 17G:81-88, 1993.
- Hardt, NS, Hendricks, JB, Sapi, Z, Tykochinsky, G, Wilkinson, E, Epstein, H, Wajsman, Z: Ploidy results in prostatic carcinoma vary with sampling method and with cytometric technique. Modern Pathology 7:44-48, 1994
- Hendricks, JB, Wilkinson, EJ: Quality control considerations for Ki-67 detection and quantitation in paraffin-embedded tissue. J Cellular Biochemistry (JCB) Supplement 19, 1994.
- Hendricks, JB, Wilkinson, EJ, Drew, P, Blaydes, SM, Kubilis, P, Munakata, S: Ki-67 Expression in Vulvar Carcinoma. Int J Gynecol Pathol 13:205-10, 1994.
- Dungar, CF, Wilkinson, EJ: Vaginal Columnar Cell Metaplasia: An Acquired Adenosis Associated with Topical 5-Fluorouracil Therapy. J Reprod Med 40:361-366, 1995.
- Allen, PM, Davis, GD, Bowen, LW, Sand, PK, Herbert, DB, Wilkinson, EJ: The Female Urethral Syndrome is Rarely Associated with Human Papillomavirus Infection Types June/11,16,18,31,33. International Urogynecology Journal 6:195-197, 1995.
- Wilkinson, EJ, Hendricks, JB: Role of the pathologist in biomarker studies. J Cell Biochem, 23(Suppl):10-18, 1995.
- Kline, MJ, Wilkinson, EJ, Askeland, R, Given, RW, Hendricks, JB: DNA Tetraploidy in Feulgen Stained Bladder Washings Assessed by Image Cytometry. Analytical and Quantitative Cytology and Histology, 17(2):129-34, 1995.
- Drew, PA, Al-Abbadi, A, Orlando, C, Hendricks, JB, Kubilis, PS, Wilkinson, EJ: Prognostic Factors in Carcinoma of the Vulva: A Clinicopathologic and DNA Flow Cytometric Study. Int J Gynecol Pathol 15:235-241, 1996.
- Hendricks, JB, Stephen, CA, Wilkinson, EJ, Szekeres: Estrogen Receptor Specific (ER1D5) Epitope Stability in Paraffin Sections. The Journal of Histotechnology 19:1-3, 1996.
- Bennett, B, Wilkinson, EJ: Frozen Section Analysis of Cervical Loop Excision Versus Cone Biopsy Before Planned Hysterectomy, Am J Obst & Gynecol, 1997
- Kim, YT, Thomas, NF, Kessis, TD, Wilkinson, EJ, Hedrick, L, Cho, KR: P53 Mutations and Clonality in Vulvar Carcinomas and Squamous Hyperplasias: Evidence Suggesting that Squamous Hyperplasias do not Serve as Direct Precursors of HPV-Negative Vulvar Carcinomas. Hum Pathol, 27(4):389-95, 1996.
- Takezawa, K, Bennett, B, Wilkinson, EJ, Hardt, N, Drew, P: Atypical squamous cell of undetermined significance in a high risk population. J Lower Genital Tract Disease, Vol. 1(4), 1997.
- Davis, JP, Connor, EE, Clark, P, Wilkinson, EJ, Duff, P: Correlation Between Cervical Cytologic results and Gram Stain as Diagnostic Tests for Bacterial Vaginosis. Amer J. Obstet. Gynecol, 1997, 177:532-535.
- Bennett, BB, Stone, IK, Anderson, CD, Wilkinson, EJ: Deep Loop Excision for Prehysterectomy Endocervical Evaluation. Amer J. Obstet, Gynecol, 176:1997.
- Takezawa, K, Bennett, BB, Wilkinson, EJ, Hardt, NS, Drew, PA: Atypical Squamous Cells of Undertermined Significance in a High Risk Population. J Lower Genital Tract Disease, 1(4):210-213, 1997.
- Al-Abbadi, MA, Russo, K, Wilkinson, EJ: Pulmonary Mucormycosis Diagnosed by Bronchoalveolar Lavage: A Case Report and Review of the Literature. Pediatr Pulmonol, 23(3):222-225, 1997.
- Bennett, B, Takezawa, K, Wilkinson, EJ, Drew, P, Hardt, NS: Atypical Glandular Cells of Undetermined Significance (AGUS) and other Glandular Cell Abnormalities in a High Risk Population. J Lower Genital Tract Disease, 2(3):132-135, 1998.
- Takezawa, K, Bennett, BB, Wilkinson, EJ, Drew, PA, Hardt, NS: Squamous Intraepithelial Lesions of the Cervix in a High Risk Population. J Lower Genital Tract Disease, 2(3):136-140, 1998.
- Sood, AK, Sordsky, JI, Gelder, MS, Buller, RE, Anderson, B, Wilkinson, EJ, Benda, JA, Morgan, LS: Primary Ovarian Sarcoma: Analysis of Prognostic Variables and Role of Surgical Cytoreduction. Cancer 82(9):1731-7, May 1998.
- Wilkinson, EJ, Malik, S: Clinical Commentary Consensus Statement, National Institutes of Health Consensus Development Conference Statement of Cervical Cancer. J Women?s Health. 7(5):604-605, June 1998.
- Trimble, CL, Diener-West, M, Wilkinson, EJ, Zaino, RJ, Kurman, RJ, Shah, KV: Reproducibility of the Histopathologic Classification of Vulvar Squamous Carcinoma and Intraepithelial Neoplasia. Accepted Journal of Lower Genital Tract Disease, 1998.
- Malik, S, Wilkinson, EJ: Pseudopagets disease of the vulva: a case report. Journal of Lower Genital Tract Diseases 3(3):July 1999
- Malik SN, Wilkinson EJ, Drew PA, et al: “Do qualifiers of atypical squamous cells of undetermined significance (ASCUS) distinguish between low and high risk patients?” Acta Cytol, 1999;43:376-380.
- Wilkinson, EJ: Protocol for the examination of specimens from patients with carcinomas and malignant melanomas of the vulva: a basis for checklists. Arch Pathol Lab Med 124:51-56, 2000.
- Jones, RW, Rowan, DM, Kirker J, Wilkinson EJ: Vulval lichen planus: progression of pseudoepitheliomatous hyperplasia to invasive vulval carcinoma. Br J Obstet Gynaecol, (submitted, 2000).
- Wilkinson, EJ: “Protocol for the examaination of specimens from patients with carcinomas and malignant melanomas of the vulva: a basis for checklists” . Cancer Committee of the American College of Pathologists. Arch Pathol Lab Med, 2000;124:51-56.
- Malik SN, Wilkinson EJ, Drew PA, et al: “Benign cellular changes in pap smears: causes, significance and terminology”, Acta Cytol 2000. (in press)
- Wilkinson EJ: “ASCCP Practice Guidelines: Management of benign cellular changes in the cervical smear”, J Lower Genital Tract Disease, 2000 (in press)
- Wilkinson EJ: “Vulvar pagetoid urothelial intraepithelial neoplasia (PUIN)” (abstract), Mod Pathol, 2000;13:134A.
- Knapik J, Yachnis AT, Ripley D, Biegel JA, Rathor, S, Hardt, NS, Talerman, A, Wilkinson, EJ: Aggressive Uterine Sarcoma with Rhabdoid Features: Diagnosis by Peritoneal Fluid Cytology and Absence of INI1 Gene Mutation. Hum Pathol 2001;32(8):884-886.
- Brown HM, Wilkinson EJ: Uroplakin-III to distinguish vulvar Paget disease secondary to urothelial carcinoma. Hum Pathol (in press 2002).
- Wilkinson EJ, Brown HM: Vulvar Paget Diseasse of Urothelial Origin: A report of three cases and a proposed classification of vulvar Paget disease. Hum Pathol (in press 2002)
- Wilkinson EJ: “Vulvar Paget Disease and Pagetoid Urothelial Intraepithelial Neoplasia” Hum Pathol (submitted 2001)
- Wilkinson EJ. Presidential Update: The health and status of the society. J. Lower Genital Tract Disease, 2001;3:127-129.
- Feezor RJ, Kasraeian A, Copeland III, EM, Schell SR, Hochwald SN, Cendan J, Drane W, Mastin S, Wilkinson E, Lind DS: Squential dermal peritumoral radiocolloid injection for sentinel node biopsy for breast cancer: The University of Florida experience. (submitted 2002)
- Hassanein AM, Mrstik ME, Hardt N, Morgan L, Wilkinson EJ: Malignant melanoma associated with lichen sclerosus in the vulva of a 10-year-old. (Submitted 2002 J Am Acad Dermatol)