Michael Clare-Salzler, M.D.
Associate Professor
Department of Pathology, Immunology and Laboratory Medicine
University of Florida College of Medicine
Gainesville, Florida

Publications
Refereed Publications-Journal articles:
    1. Terada, M., Clare-Salzler, M.J., Lennartz, K., Mullen, Y.  The effects of H-2 compatibility on pancreatic beta cell survival in the non-obese diabetic mouse.  Transplantation 1988; 45:622-627.
    2. Mullen,Y., Taura, Y., Ozawa, A., Miyazawa, K., Clare-Salzler, M.J., Reversal of experimental diabetes in miniature swine of fetal pancreas allografts.  Transplantation Proceedings 1989; 21:2671-2672.
    3. Yoneda, K., Mullen, Y., Stein, E., Clare-Salzler, M.J., Ozawa, A., Shevlin, L., Danilvos, J.  Fetal pancreas transplantation in miniature  swine II survival of fetal pig pancreas allografts cultured at room temperature.  Diabetes 1989; 38:213.
    4. Mullen, Y., Clare-Salzler, M.J., Stein, E., Clark, W.:  Islet transplantation for the cure of diabetes.  Pancreas 1989; 4:123-135.
    5. Nagata M., Mullen Y., Matsuu S., Herrera M., Clare-Salzler M. Destruction of islets isografts by severe nonspecific inflammation.  Transplant. Proc. 1990; 22:855-856
    6. Matsuo, S., Mullen Y., Wicker L.S., Peterson L.B., Nagata T. Tsunoda T.  Clare-Salzler M.  Prolongation of  islet isograft survival in diabetic NOD mice by anti-L3T4 and anti-Lyt2 monoclonal antibodies. Transplant. Proc. 1990; 22:880-881. 
    7. Clare-Salzler, M.J., Van Herle, A.J., Varki, N.M., Tillisch, J.  Endocardial metastases of follicular thyroid carcinoma: A case report and review of the literature.  European Journal of Surgical Oncology 1991; 17:219-223
    8. Jocobs, E. L., Clare-Salzler M.J., Chopra I.J., Figlin R.A., Varki. Thyroid function abnormalities associated with chronic outpatient demonstration of recombinant Interleukin-2 and recombinant Interferon-alpha.  Journal of Immunotherapy 1991; 10:448-455
    9. Riley, W.J., et al: A prospective study of the development of diabetes in relatives of patients with insulin-dependent diabetes.  Summary and comments by M.J. Clare-Salzler.  Diabetes Spectrum 1991; 4:225-226
    10. Kaufman, D.L., Erlander, M.G., Clare-Salzler, M.J., Atkinson, M., Maclaren N. K., and Tobin A.J. GAD autoimmunity in IDDM. Diabetes 1991:Proceedings of the 14th International Diabetes Federation Congress, In: H. Rifkin, J.A., Colwell, S.I. Taylor, (Eds.). Elsevier Science Publishers,  Amsterdam,   1991;415
    11. Kaufman, D., Erlander, M., Clare-Salzler, M.J., Atkinson, M.,  Maclaren, N., Tobin, A.  Autoimmunity to two forms of glutamate decarboxylase in insulin dependent  diabetes mellitus. Journal of Clinical Investigation 1992; 89:283-292.
    12. Clare- Salzler, M.J., Kaufman, D., Tobin, A. Glutamate decarboxylase on IDDM autoantigen.  Diabetes Care 1992; 15:132-135.
    13. Clare-Salzler, M.J., Mullen, Y.  Marked dendritic cell-T cell cluster formation in the pancreatic lymph node of the non-obese diabetic mouse.  Immunology 1992; 76:478-484.
    14. Clare-Salzler, M.J., Brooks, J., Van Herle, K., Chai, A., Anderson, C. Prevention of diabetes in NOD mice by dendritic cell transfers. Journal of Clinical Investigation 1992; 90:741-748.
    15. Gottschalk, M., Schatz, D.A., Clare-Salzler, M.J., Kaufman, D.L.+, Ting, G.S.P., Geffner, M.E.  Permanent non-autoimmune diabetes following transient neonatal diabetes.  Diabetes Care 1992; 15:1273-1276.
    16. Kaufman, D.L., Clare-Salzler, M.J., Tian, J., Forsthuber, T., Ting, G.S.P., Robinson, P., Atkinson, M.A., Sercarz, E.E., Tobin, A.J., Lehmann, P.  Spontaneous loss of T cell tolerance to glutamate decarboxylase is a key event in the pathogenesis of murine insulin-dependent diabetes.  Nature 1993; 366:69-72.
    17. Geffner, ME., Clare-Salzler M.J., Kaufman D.L., Ting, G., Gottschalk, M.E., and Schatz D. Permanent non-autoimmune diabetes following transient neonatal diabetes.  Lancet 1993; 341:1095.
    18. Deng, H-K., Clare-Salzler, M.J., Geysen, M., Sercarz, E.E.  A determinant capture model in the NOD mouse responsive to hen egg lysozyme.  Journal of Experimental Medicine 1993; 178:1675-1680. 
    19. Clare-Salzler, M.J., Mullen, Y., Chai, A., Stein, E., Girman, D., Lennartz, L.  Effect of H-2 compatibility in autoimmune destruction of islet allografts from B10 congenic lines to non-obese diabetic mice.  Pancreas 1994; 9:179-185.
    20. Muir, A., Peck, A., Clare-Salzler, M.J., Song, Y-H., Cornelius, J., Luchetta, R., Krischer, J., Maclaren, N.  Insulin immunization of NOD mice induces a protective insulitis characterized by diminished intra-islet interferon-gamma transcription.  Journal of Clinical Investigation 1995; 95:628-634.
    21. Cornford, E.M., Hyman, S., Cornford, M.E., Clare-Salzler, M.J., Down-Regulation of blood-brain glucose transport in the hyperglycemic nonobese diabetic mouse.  Neurochem. Res.  1995; 20:869-873.
    22. Benhamou, P.Y., Mullen, Y., Clare-Salzler, M.J., Sanckhard, A., Benhamou, C., Go, V.L.   Protective effects of dietary fatty acids on autoimmune diabetes in NOD mice.  Pancreas 1995; 11:26-35.
    23. Tian J, Atkinson M.A, Clare-Salzler, M.J., Herschenfeld, A.  Forsthuber T,  Lehmann P.V.  Kaufman D.L.  Nasal administration of glutamate decarboxylase (GAD65) peptides induces a Th2 and prevents murine insulin dependent diabetes. J. Exp. Med. 1996;  183:1561-1567.
    24. Tian,J., Clare-Salzler,  M.J., Herschenfeld,  A.,  Middleton, B., Newman, D.,  Evans, C.,  Atkinson, M.A., Miller, R., Mullen, Y., Sarvetnick, N., Tobin, A.J., and Kaufman, D.L.  Glutamate decarboxylase administration inhibits disease  progression in pre-diabetic mice and prolongs survival of transplanted islets in diabetic mice.  Nature Med. 1996; 2:1348-1358. 
    25. Solorzano, C.C., Pruitt, J.H., Ksontini, R., Hess, P. J., Edwards, P. D., Kaibara, A, Aboulhamze,  A., Auffenberg,  T., Galardy,  R. E., Vauthey,  J.N., Copeland,  E.M., Edwards,  C.E., Lauers,  G.Y.,  Clare-Salzler, M.J., MacKay,  S.L.D., Moldawer,  L. L.,  Lazarus D.  Involvement of 26kD cell associated TNF-? in experimental hepatitis and exacerbation of liver injury with a matrix metalloproteinase inhibitor. J.  of Immunol.  1997, 158:413-418.
    26. Ksontini, R., Colagiovanni, D.B., Josephs, M.D., Edwards, D.K.III,  Tannahill,C.L., Solorazano, C.C., Norman J., Denham, W., Clare-Salzler,M.J., Mackay, S.L.D., Moldawer, L.L.  Disparate Roles for TNF and Fas Ligand in Concanavalin A-Induced Hepatitis. J. Immunol.  1998, 160:4082-4089.
    27. Gulig P.A., Doyle T.J., Clare-Salzler M.J., Maiese R., Matsui H.  Systemic infection of mice by wild-type but not SPV- Salmonella typhimurium is enhanced by neutralization of interferon-? and tumor necrosis factor-?.  Infect. and Immun. 1997; 65:5191-5197.
    28. Solorazano, C.C., Kaibara A., Hes P.J.., Edwards P.E., Ksontaini R., Abouhamze A., McdanielS., Frazier J., Trujillo D., Keift G., Seely J., Kohno T., Cosenza M.E., Clare-Salzler M., Mackay S.L.D., Martin S.W., Moledawer L..L., Edwards C.E., 3rd. Pharmacoknetics, immunogenicity, and efficacy of dimeric TNFR binding proteins in healthy and bacteremic baboon. J. Appl. Physiol. 1998, 84:1119-11130.
    29. Litherland, S.A., Xie, Hutson, A. D., Wasserfall, C., D.S. Whittaker, Clare-Salzler, M.J. et.al: Aberrant prostaglandin synthase 2 expression defines and antigen-presenting cell defect for insulin-dependent diabetes mellitus. J. of Clin. Investigation. 1999, 14(4) 515-19.
    30. Fukuzuka,K., Moldawer, L.L., Edwards, C.K. Clare-Salzler, M.J., Caspase-3 dependent organ apoptosis early after burn injury.  Ann of Surg. 1999, 229(6):851-8:discussion 858-9.
    31. Maclaren, N., Lan, M., Coutant, R., Schatz, D., Silverstein, J. Muir, A., Clare-Salzler, M.J.  Only multiple autoantibodies to islet cells (IGA), insulin, GAD65, Ia-2 and IA-2beta predict immune-mediated (type 1) diabetes relatives. J. Autoimmunity.  1999, 12 (4): 279-87.
    32. Ottendorfer E., Ellis T. M., Bahjat K.S., Clare-Salzler, M., Atkinson M.A. No alteration in T lymphocyte expression of CD40 ligand (CD154) individuals with or at increased risk for insulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 1999, 84:4068-72.
    33. Fukuzuka, K. Edwards, C.K., Clare-Salzler, M.J., Copeland, E.M.III, Moldawer, L.L. Glucocorticoid indeed, caspase-dependent organ apoptosis early after burn injury. Am. J. Physiology 1999, 278:R1005-18.
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     BOOKS, CONTRIBUTOR OF CHAPTERS: 

    1. NOD Mice and Related Strains:Research Applications in Diabetes,  AIDS, Cancer, and Other Diseases.  Editor:  Ed Leiter, Ph.D.;  Springer Verlag, 1998.  Chapter IV. The Immunopathogenic Role of Antigen Presenting Cells in the NOD Mouse. Pg. 101-113.
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     Published Abstracts:
     

    1. Clare-Salzler, M., Mullen, Y.  Abnormal dendritic cell function in NOD mouse.  American Diabetes Association Meeting in Indianapolis, Indiana, 1987.  Diabetes 1987; 36(Suppl 1):68A.
    2. Lipshutz, G, Clare-Salzler, M.J., Newborn pancreas but not submandibular gland isografts are destroyed in NOD mice with severe insulitis and sialitis.  American Diabetes Association Meeting in Detroit, MI, June 1989.  Diabetes 1989; 38(Suppl 2):187A.
    3. Clare-Salzler, M.J., Chai, A, Mullen, Y.  Submandibular gland antibodies in the NOD mouse.  American Diabetes Association Meeting in Detroit, MI, June 1989.  Diabetes 1989; 38(Suppl 2):187A.
    4. Nagata, M, Mullen, Y., Matsuo, S., Herrera, M., Clare-Salzler, M.J., Destruction of islet isografts by severe nonspecific inflammation.  Congress on Pancreatic and Islet Transplantation in Minneapolis, MN, September 1989.  Transplantation Proceedings 1990; 22:855.
    5. Matsuo, S., Mullen, Y., Wicker, L., Peterson, L., Nagata, M., Clare-Salzler, M.J., Prolongation of islet isograft survival in diabetic NOD mice by anti-L3T4 and anti-Lyt2 MOAb. Congress on Pancreatic and Islet Transplantation.  Transplantation Proceedings 1990; 22:880.
    6. Clare-Salzler, M.J., Brooks, J., Chai, A., Van Herle, K., Anderson, C.  In vivo effects of pancreatic lymph node dendritic cells in NOD mice.  14th International Diabetes Federation Congress in Washington, DC, June 1991.  Diabetes 1991;40(Suppl):206.
    7. Tobin, A.J., Atkinson, M.A., Bu, D.F., Clare-Salzler, M.J., Erlander, M.G., Feldblum, S., Houser, C., Kaufman, D.L., Maclaren, N.K., Patel, N., Pinal, C., Tillakante, N.J.K.  Autoantibodies in IDDM patients differentially recognize two forms of glutamate decarboxylase, which derive from two genes.  14th International Diabetes Federation Meeting in Washington, DC, June 1991.  Diabetes 1991; 40(Suppl):6.
    8. Deng, H-K., Clare-Salzler, M.J., Geysen, M., Sercarz, E.  A determinant capture model in the NOD mouse responsive to HEL.  Keystone Symposium on Antigen Presentation Functions of the MHC in Taos, NM, March 1992.  Journal of Cellular Biochemistry Supl.16D,1992.
    9. Clare-Salzler, M.J., Robinson, P., Kaufman, D., Evans, C., Tobin, A., Peck, A.  The ontogeny of NOD spleen cell responses (SCR) to glutamate decarboxylase and other defined autoantigens in NOD mice.  Submitted to the American Diabetes Association Meeting in San Antonio, TX, June 1992.  Diabetes 1992; 41(Supple): 99.
    10. Robinson, P., Cai, B., Keenen, C., Wong, V., Sherman, M., Clare-Salzler, M.J., Macrophage factors mediate suppression of the SMLR in NOD mouse.  Autoimmunity 1993; 15(Suppl):49.
    11. Molldrem, J. Robinson, P., Sherman, M., Wong, V., Cefalu, W., Clare-Salzler, M.J., Advanced glycation endproducts induce nitric oxide secretion by peritoneal macrophages in NOD mice.  Journal of Immunology 1993; 150(Suppl):978.
    12. Khan, B., Robinson, P., Wong, V., Sherman, M., Clare-Salzler, M.J., Cholesterol uptake affects nitric oxide production by macrophages in NOD and BALB/c mice.  Autoimmunity 1993; 15(Suppl):46.
    13. Robinson, P., Ayroso, V., Peck, A., Kaufman, D. Clare-Salzler M.J. Protection from diabetes by dendritic cell transfer in NOD mice: Cytokine patterns of responding T cells and dependence on exposure to islet antigens.  Autoimmunity 1993; 15(Suppl):86.
    14. Khan, B., Robinson, P., Wong, V., Sherman, M., Clare-Salzler, M.J., NOD mouse macrophages demonstrate enhanced uptake of modified LDL cholesterol and suppression of nitric oxide.  Journal of Immunology 1993; 150(Suppl):288.
    15. Robinson, P, Serreze, D., Middleman, S, Molldrem, J. Deng, H.K., Clare-Salzler, M.J., Transformed NOD macrophage lines: phenotypic, functional and genetic analysis. Diabetes 1994; 43:235A. 
    16. Clare-Salzler, M.J., Tian, J., Kaufman, D.  Effects on GAD65 treatment on NOD islet histology and sialitis.  Diabetes 1994; 43:93A.
    17. Lehmann, P.V., Kaufman, D.L., Clare-Salzler, M.J., Tian, J., Forsthuber, T., Sercarz, E.E.  Spreading of autoantigen recognition in autoimmunity.  The FASEB Journal 1994; 8(4):A204.
    18. Benhamou, P.Y., Mullen, Y., Clare-Salzler, M.J., Sangkharat, A., Benhamou, C., Shevlin, L., Go, V.L.W.  Protective effects of dietary fatty acids on autoimmune diabetes in NOD mice.  The FASEB Journal 1994; 8(4):A815.
    19. Kaufman, D.L., Tian, J., Lehmann, P.V., Forsthuber, T., Newman, D., Atkinson, M.A., Sercarz, E.E., Tobin, A.J., Clare-Salzler, M.J., Induced tolerance to peptides of glutamate decarboxylase (GAD65) prevents murine insulin-dependent diabetes.  The FASEB Journal 1994; 8(4):A978.
    20. Clare-Salzler, M.J., Robinson, P, Cornelius, J., Anderson, J., Peck, A.  Dendritic cell transfers protect non-obese diabetic (NOD) mice from diabetes;dependence on islet antigen exposure and modification of cytokine profiles of islet infiltrating cells.  J. Cell. Biochem. Supl. 21A:24,1995. 
    21. Xie, T., Hofig, A., Reddy, S., Herschman, H., Clare-Salzler, M.J, Spontaneous expression of the immediate early response gene prostaglandin synthase 2(PGS-2) in the NOD macrophage.  Diabetes  44:Supl.1, 79a, 1995. 
    22. Xie, T., Yui, M., Hofig, A., Reddy S., Herschman, H., Wakeland, E., Clare-Salzler, M.J., Control of prostaglandin synthase 2 expression in NOD macrophages. Diabetes 44:Supl. 1, 240, 1995.
    23. Xie, T., Hofig, A., Yui M., Wakeland, E., Reddy, S., Herschman, H., Wicker, L., Peterson, L., Clare-Salzler, M.J., Spontaneous Prostaglandin Synthase-2 expression in macrophages of NOD and congenic mice.  Autoimmunity  21:17, 1995. 
    24. Hofig A., Xie, T., Litherland, S., Schatz, D., Maclaren, N., Moldawer, L., Clare-Salzler, M.J., Spontaneous expression of prostaglandin synthase-2 expression in monocytes of ICA positive-pre-diabetic subjects.  Autoimmunity  21:18, 1995.
    25. Litherland, S., Xie T., Hofig, A., Anderson, J, Robinson, C., Clare-Salzler, M.J., Characterization of suppression activity derived from regulatory cells of the NOD pancreatic lymph node.  Autoimmunity 21:29, 1995.
    26. Xie, T., Reddy, S., Hofig, A., Litherland, S.A., Herschman, H., Myrick, C., Wakeland, E., Peterson, L., Wicker L., Clare-Salzler, M.J., Regulation of prostaglandin synthase (PGS-2) expression in NOD macrophages.  Autoimmunity 2:29, 1995.
    27. Litherland, S.A., Hofig, A., Xie T., Schatz, D., Maclaren N., Clare-Salzler, M.J., Individuals at risk for IDDM spontaneously express prostaglandin synthase 2 (PGS2) in the absence of monocyte activation.  Autoimmunity 1995 2:30.
    28. Clare-Salzler, M.J., Soloarzano C.C., Josephs M.D., Edwards C.K. Tumor Necrosis Factor binding protein (TNF-bp) reduces neutropenia and loss of FAS positive peripheral blood leukocytes in septic baboons. Shock  1997 7:117.
    29. Bahjat, K., Clare-Salzler M.J. CPP32 Dysregulation in NOD mice.  Immunology of Diabetes Society Proceedings, Chicago, IL, 1998
    30. Litherland S.A., Xie T. X., Whittaker D.S., Schatz D., Moldawer L.L., Clare-Salzler M.J.  Aberrant Monocyte Prostaglandin Synthase-2 (PGS-2) expression: A novel cellular marker for IDDM risk. Immunology of Diabetes Society Proceedings, Chicago, IL, 1998.
    31. Litherland S.A., T. X., Whittaker D.S., Moldawer L.L., Clare-Salzler M.J. Monocyte Prostaglandin synthase 2 (PGS2) produced prostaglandin E2 (PGE2) inhibits activated T cell IL2 and Il2 receptor alpha (CD25) expression:A mechanism for the loss of T cell tolerance in immune mediated diabetes(IMD). Immunology of Diabetes Society Proceedings, Chicago, IL, 1998.
    32. Whittaker D.S., Clare-Salzler M.J.  Human monocyte derived dendritic cells (DC) express prostaglandin synthase-2 Impact on DC function. Presented at the Cellular and Molecular Biology of Dendrite Cells. Keystone Symposia on Dendritic Cell Biology, Santa Fe, N.M. March 1998
    33. Whittaker, DS Clare-Salzler M.J.,  Characterization of monocyte derived dendritic cells (DC) from pre-IDD subjects: Effects of endogenous prostanoids on IL-12 production. Immunology of Diabetes Society Meeting Proceedings 1998. 
    34. Litherland,A., Whittaker, K.M., Grebe, Clare-Salzler, M.J., Autoimmunity & Tolerance. Dysregulation of Prostaglandin Synthase 2 (PGS2) in Autoimmunity: IL10 Resistance & STAT5 Regulation. Keystone Meeting, Autoimmunity and Tolerance, April, 1999.
    35. Bahjat K.S., Bahjat F.R., Whitaker D.S., Xie T., Wakeland E., Auffenberg T., L. L., Moldawer, Clare-Salzler, M.J. Defect in AICD in the NOD mouse. Keystone Meeting, Autoimmunity and Tolerance, April, 1999. 
    36. Whittaker, D.S., Clare-Salzler M. J. Divergent regulation of IL-12 by PGE2 in monocyte derived dendritic cells. Keystone Meeting, Autoimmunity and Tolerance, April, 1999.
    37. Litherland, S.A., Xie,T.,Muir, A., Clare-Salzler, M.J.. Prostaglandin Synthase 2 Expression as a Risk Assessment Tool for IDDM. A New Avenue for Prevention & Intervention?  Immunology of Diabetes Society Proceedings, 1999
    38. Bahjat, K.S., Whittaker, D.S., Moldawer, L.L., Clare-Salzler, M.J., etc. Regions of NOD mouse chromosome 17 and chromosome 1 control AICD in the NOD Mouse. Immunology of Diabetes Society Meeting Proceedings, 1999 
    39. Litherland, S.A., Xie T., Muir A., Schatz D., She J-X., Atkinson M., Clare-Salzler M.J.  Prostaglandin Synthase 2 expression as a risk assessment tolol fo IDDM:A new avenue for prevention and intervention? Immunology of Diabetes Meeting Proceedings, 1999.
    40. Bahjat, F.R., Clare-Salzler, M.J., Moldawer, L.L., Genetic Determination of TNF?? Mediated Liver apoptosis. 5th World Congress on Trauma, Shock, Inflammation and Sepsis, 2000.
    41. Bahjat F.R.  Clare-Salzler, M.J., Moldawer L.L. Genetic polymorphism in the response to lipopolysaccharide and D-galactosamine in the mouse. Surgical Infection Society 2000.
    42. Mizutani A., Behney K.M., Litherland S.A., Clare-salzler M., Richards H.B., Reeves W.H. Malleability of autoimmune disease phenotypes. Submitted to the American College of Rheumatology (ACR) 64th Annual Scientific meeting, Philadelphia PA.
    43. Litherland S.A., Xie T., Davoodi-Semironi R., Schatz D., Clare-Salzler M.J.  Prolonged GM-CSF activation of STAT5 in type 1 diabetes:Possible mechanism for aberrant prostaglandin synthase 2 (PGS2) expression by autoimmune monocytes and macrophages.  2000 FASEB Summer Research Conference 
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     Poster Presentations at International Meetings Which Were Not Published As Abstracts:
     

    1. Clare-Salzler, M.J.,  Robinson P.,  Cornelius,  J.,  Anderson,  J., Peck, Modification of intra-islet Cytokine mRNA expression in NOD mice receiving pancreatic lymph node (PLN) dendritic cell transfers.  Presented at the 13th IDW meeting, Chantilly, France, 1995.
    2. Clare-Salzler, M.J., Robinson, P. Deleterious effects of macrophage on dendritic cell T cell interactions in the NOD mouse.  Presented at the 13th IDW meeting, Chantilly, France, 1995.
    3. Clare-Salzler, M.J., Chai, A., Mullen, Y.  The effect of H-2 compatibility on Beta cell survival in the NOD mouse.  Immunology of Diabetes in Woodshole, MA, October 1987.
    4. Clare-Salzler, M.J., Chai, A., Mullen, Y. Characteristics of dendritic cell-lymphocyte clusters in the NOD mouse. Immunology of Diabetes in Woodshole, MA, October 1987. 
    5. Clare-Salzler, M.J., Jacobs, E., Chopra, I., Figlin, R.  Thyroid function abnormalities associated with recombinant IL-2 and Interferon Alpha outpatient therapy.  National American Federation of Clinical Research Meeting , Seattle, WA., May ,1991.
    6. Clare-Salzler, M.J., Atkinson, M., Ting, G., Robinson, P., Tian, J. D., Newman, D., Erlander, M., Phan, T., Maclaren, N.K., Tobin, A., Kaufman, D.  Autoimmunity to glutamate decarboxylases GAD65 and GAD67.  Neuroscience Meeting, Anaheim, CA, October 1992.
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     Manuscripts in press or submitted Refereed  Publications-Journal Articles:
     

    1. Whittaker D.S., Bahjat K.S., Moldawer L.L., Clare-Salzler M. J. Cyclooxygenase-2 mediated prostanoid production regulates human monocyte derived dendritic cel maturation and IL-12 production.  (submitted; J. of Immunol.).
    2. Fukuzuka K., Edwards C.K. III, Clare-Salzler, M., Copeland E.M. III, Moldawer LL., Mozingo D.W.  Glucorticoid and Fas ligand induced mucosal lymphocyte apoptosis after burn injury (submitted; J. of Trauma).
    3. Oberholzer, C., Oberholzer A., Clare-Salzler M., Moldawer LL. Apoptosis as a potential therapeutic target in critically ill septic patients. (submitted:Blood)
    4. Donna S. Whittaker*, Keith S. Bahjat*, Clive Wasserfall*, Lyle L. Moldawer†, and Michael J. Clare-Salzler*† Maturation stimuli and modulation of prostaglandin receptors regulate the effects of PGE2 on interleukin-12 production by immature and maturing monocyte derived dendritic cells. (submitted:J. Immunol.)
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     Manuscripts in preparation:
     

    1. Clare-Salzler, M.J., Robinson, P., Peck, A., Kaufman, D., Aryoso V. Dendritic cell transfer protects NOD mice form diabetes: Cytokine message in responding T cells, and dependence on exposure to islet antigens.
    2. Litherland, S.A., Morano-Salchez, D. Whittaker,D. Clare- Salzler,M.J, Autoimmune Monocyte Prostaglandin synthase 2 Activity Impairs    Activation Induced Cell Death to T cells by Suppressing IL2 Signaling. 
    3. Litherland S.A., Xie, T. Grebe,K.M., Whittaker, D., Clare-Salzler, M., Regulatory Defect in Autoimmune PGS2 Expression Involves IL10 Resistance and STAT5 Dysfunction. 
    4. Litherland,S.A., Xie,T., Anderson, C., Peck, A., Clare-Salzler, M.J, Characterization of Soluble Suppression Factor(s) Derived from Regulatory T Cells of the NOD Pancreatic Lymph Node. 
    5. Xie, T, Hofig, A. Reddy,S., Clare-Salzler, M.J., Dysregulation of PGS-2 expression in the macrophage of the NOD mice is controlled by two genetic loci on chromosome 1.
    6. Bahjat,K. Whittaker, D.S., Clare-Salzler, M.J., T cell activation and apoptosis in the NOD mouse are controlled by genes within IDD1 and IDD5.