We aim to modulate specific immune responses by targeting the key proteins involved with antigen processing and presentation to T lymphocytes. Understanding atomic interactions that determine T cell recognition provides the basis for the design of compounds that can be functionally evaluated in vitro and in vivo.

• Clinical applications:

Enhancing Immunity - A significant goal of the laboratory is to generate enhanced T cell responses against specific tumor antigens and infectious pathogens (e.g., HIV, CMV).

Antigen specific tolerance - It would be beneficial to weaken T cell responses to specific antigens in preventing graft-versus-host disease and autoimmune diseases such as Type I Diabetes, Rheumatoid Arthritis, Systemic Lupus Erythematosis and allergic asthma.

• Structure Based Modulation of Atopic Asthma
• Structural Genomics & Proteomics of the Major Histocompatibility Complex
      - Relative Risk & LOD Score Diagram
      - Gene Function List
• Assorted Images Pertaining To HKE2