Dept.
of Pathology, Immunology and Laboratory Medicine
University of Florida College of Medicine
P.O. Box 100275
Gainesville, FL 32610-0275
Office Location and Express
Mail address:
Dept. of Pathology, Immunology and Laboratory Medicine
University of Florida College of Medicine
D6-18B
1600 SW Archer Road
Gainesville, FL 32610-0275
Primary Area of Research:
We use X-ray crystallography to answer questions regarding immune recognition. In addition, we use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined with functional testing in vitro and in vivo.
Ostrov, D. A., W. Shi, J. C. Schwartz, S. C. Almo, and S. G. Nathenson. 2000. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 290:816.
Hernandez Prada, J. A., R. N. Haire, M. Allaire, J. Jakoncic, V. Stojanoff, J. P. Cannon, G. W. Litman, D. A. Ostrov. 2006. Ancient Evolutionary Origin of Diversified Variable Regions Revealed by Crystal Structures of an Amphioxus VCBP. Nature Immunology, 7(8) 875-882.
J. P. Cannon, R. N. Haire, A. T. Magis, D. D. Eason, K. N. Winfrey, J. A. Hernandez Prada, K. M. Bailey, J. Jakoncic, G. W. Litman and D. A. Ostrov. 2008. Novel Immune-Type Receptors Mediate Allogeneic Recognition. In press, Immunity.
