David A. Ostrov, PhD
Assistant Professor
Department of Pathology, Immunology and Laboratory Medicine
University of Florida College of Medicine
Gainesville, Florida

Publications (Please see Curriculum Vitae for complete list)
       

      Publications:

      1. Hernández Prada, J.A., Haire, R.N., Allaire, M., Jakoncic, J., Stojanoff, V., Cannon, J.P., Litman, G.W., Ostrov, D.A. Ancient Evolutionary Origin of Diversified Variable Regions Revealed by Crystal Structures of an Amphioxus VCBP. In press, Nature Immunology, 2006.
      2. Sandberg, E.M., VonDerLinden, D., Ostrov, D.A., Sayeski, P.P. Identification of cyclohexane-1,2,3,4,5,6-hexabromo- as a small molecule inhibitor of Jak2 tyrosine kinase autophophorylation. J. Medicinal Chemistry, 265:161-9. 2005.
      3. Yoder, J.A., Litman, R.T., Mueller, M.G., Desai, S., Dobrinski, K.P., Montgomery, J.S., Buzzeo, M.P., Ota, T., Amemiya, C.T., Trede, N.S., Wei, S., Djeu, J.Y., Humphray, S., Jekosch, K., Hernandez Prada, J.A., Ostrov, D.A., and Litman, G.W. Resolution of the novel immune-type receptor gene cluster in zebrafish. Proc Natl Acad Sci U S A 101:15706-11, 2004.
      4. Santori, F.R., Holmberg, K., Ostrov, D., Gascoigne, N.R., and Vukmanovic, S. Distinct footprints of TCR engagement with highly homologous ligands. J Immunol 172:7466-75. 2004.
      5. Sandberg, E.M., VonDerLinden, D., Ostrov, D.A., Sayeski, P.P.. Jak2 tyrosine kinase residues glutamic acid 1024 and arginine 1113 form a hydrogen bond interaction that is essential for Jak-STAT signal transduction. Mol. Cell. Biochem. 265:161-9. 2004.
      6. Huentelman, M.J., Zubcevic, J., Hernandez Prada, J.A., Xiao, X., Dimitrov, D.S., Raizada, M.K., and Ostrov, D.A. Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor. Hypertension 44:903-6. 2004,
      7. Hernandez Prada, J.A., Haire, R.N., Cannon, J.P., Litman, G.W., and Ostrov, D.A. Crystallization and preliminary X-ray analysis of VCBP3 from Branchiostoma floridae. Acta Crystallogr D Biol Crystallogr 60:2022-4. 2004.
      8. Eason, D.D., Cannon, J.P., Haire, R.N., Rast, J.P., Ostrov, D.A., and Litman, G.W.. Mechanisms of antigen receptor evolution. Semin Immunol 16:215-26. 2004.
      9. Becker, M.N., Greenleaf, W.B., Ostrov, D.A., and Moyer, R.W.. Amsacta moorei entomopoxvirus expresses an active superoxide dismutase. J Virol 78:10265-75. 2004.
      10. Ostrov, D. A., Roden, M.M., Shi, W., Palmieri, E., Christianson, G.J., Mendoza, L., Villaflor, G., Tilley, D., Shastri, N., Grey, H., Almo, S.C., Roopenian, D.. and Nathenson, S.G.. How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination. J Immunol 168:283-9. 2002.
      11. Zhang, W., Honda, S., Wang, F., DiLorenzo, T.P., Kalergis, A.M., Ostrov, D.A., and Nathenson, S.G. Immunobiological analysis of TCR single-chain transgenic mice reveals new possibilities for interaction between CDR3 a and an antigenic peptide bound to MHC class I. J Immunol 167:4396-404. 2001.
      12. Ostrov, D.A., Shi, W., Schwartz, J.C., Almo, S.C., and Nathenson, S.G. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 290:816-9. 2000.
      13. Melian, A., Watts, G.F., Shamshiev, A., De Libero, G., Clatworthy, A., Vincent, M., Brenner, M.B., Behar, S., Niazi, K., Modlin, R.L., Almo, S., Ostrov D.A., Nathenson, S.G. and Porcelli, S.A. Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with aß TCRs. J Immunol 165:4494-504. 2000.
      14. Hansen, T., Balendiran, G., Solheim, J., Ostrov, D.A., and Nathenson, S. Structural features of MHC class I molecules that might facilitate alternative pathways of presentation. Immunol Today 21:83-8. 2000.

      Invited Lectures:

      1. Structures of CTLA-4 (CD152) and the Mouse Minor Histocompatibility Antigen H13: Implications on Graft Tolerance. Division of Immunology, The Jackson Laboratory, Bar Harbor, ME, September 1, 1999.
      2. Crystal Structures of CTLA-4 (CD152) and the H13 Minor Histocompatibility Antigen: Implications on Graft Rejection. Biogen, Cambridge, MA, September 24, 1999.
      3. Binding Rules Broken: How to Cope? Antigen Processing and Presentation Meeting, The Jackson Laboratory, Bar Harbor, ME, October 16-18, 1999.
      4. Invited to co-chair session on Class I and Class II MHC Structure. 11th International Congress of Immunology, Stockholm, Sweden, July 22-28, 2001.

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