David A. Ostrov, PhD
Assistant Professor
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Dept. of Pathology, Immunology and Laboratory Medicine |
Currently Involved In:
We use X-ray crystallography to answer questions regarding immune recognition. In addition, we use methods in structure-based drug design to discover and develop novel therapies for human diseases. We are actively targeting cardiovascular diseases, cancer and diabetes by high-throughput virtual screening combined with functional testing in vitro and in vivo.
Select Publications:
Ostrov, D. A., W. Shi, J. C. Schwartz, S. C. Almo, and S. G. Nathenson. 2000. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 290:816.
Hernandez Prada, J. A., R. N. Haire, M. Allaire, J. Jakoncic, V. Stojanoff, J. P. Cannon, G. W. Litman, D. A. Ostrov. 2006. Ancient Evolutionary Origin of Diversified Variable Regions Revealed by Crystal Structures of an Amphioxus VCBP. Nature Immunology, 7(8) 875-882.
J. P. Cannon, R. N. Haire, A. T. Magis, D. D. Eason, K. N. Winfrey, J. A. Hernandez Prada, K. M. Bailey, J. Jakoncic, G. W. Litman and D. A. Ostrov. 2008. Novel Immune-Type Receptors Mediate Allogeneic Recognition. In press, Immunity.
Find out more about the Ostrov lab:
General webpage:
http://www.med.ufl.edu/IDP/BMB/bmbfacultypages/dostrov.html
Cancer:
http://www.rgp.ufl.edu/publications/explore/current/story_3/
Hypertension/heart disease:
http://news.ufl.edu/2008/05/01/heart-effects/
http://news.ufl.edu/2008/05/01/ace/
http://www.gainesville.com/article/20080623/NEWS/806230306
http://www.genengnews.com/genCasts.aspx?id=213
http://www.pharmaquality.com/pfq_news_07_2008_003.html
http://www.drugdiscoverynews.com/index.php?newsarticle=2215
Immune system:
http://news.ufl.edu/2006/10/03/immune/
http://news.health.ufl.edu/news/tape.aspx?ID=195
http://www.underwatertimes.com/news.php?article_id=83410560791
Drug Discovery:
http://my.ufscc.ufl.edu/memarea/sbdd/index.htm