David A. Ostrov, PhD
Associate Professor
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Dept. of Pathology, Immunology and Laboratory Medicine |
Currently Involved In:
Our group utilizes methods in structure-based drug design to discover and develop novel therapies for preventing and treating human diseases. The laboratory has experience employing a diverse set of biophysical techniques including X-ray crystallography to answer questions regarding immune recognition. Our team focuses on developing novel therapeutic approaches to treat esophageal cancer, breast cancer, drug resistant childhood leukemia, colon cancer, lung cancer, prostate cancer, lymphoma, Type I diabetes, Graft Versus Host Disease, Rheumatoid Arthritis, Autism Spectrum Disorders and drug resistant pathogens including HIV. Our laboratory developed a unique rapid and economical method to combine in silico high-throughput screening with functional structure-activity-relationship testing in vitro and in vivo.
Select Publications:
- Prediction of Off-Target Effects on Angiotensin-Converting Enzyme 2.
Kulemina LV, Ostrov DA.
J Biomol Screen. 2011 Aug 22. [Epub ahead of print]
PMID: 21859683 [PubMed - as supplied by publisher]
Related citations
- A Novel Small Molecule Inhibitor of FAK And IGF-1R Protein Interactions Decreases Growth of Human Esophageal Carcinoma.
Ucar DA, Cox A, He DH, Ostrov DA, Kurenova E, Hochwald SN.
Anticancer Agents Med Chem. 2011 Jun 27. [Epub ahead of print]
PMID: 21707510 [PubMed - as supplied by publisher]
Related citations
- Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth.
Ucar DA, Kurenova EV, Garrett TJ, Cance WG, Nyberg CD, Cox AL, Massoll NA, Ostrov DA, Lawrence NJ, Sebti SM, Hochwald SN.
Carcinogenesis. 2011 Jul 19. [Epub ahead of print]
PMID: 21666222 [PubMed - as supplied by publisher]
Related citations
- Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate.
Shroads AL, Langaee T, Coats BS, Kurtz TL, Bullock JR, Weithorn D, Gong Y, Wagner DA, Ostrov DA, Johnson JA, Stacpoole PW.
J Clin Pharmacol. 2011 Jun 3. [Epub ahead of print]
PMID: 21642471 [PubMed - as supplied by publisher]
Related citations
- Functional expression of human adenine nucleotide translocase 4 in Saccharomyces cerevisiae.
Hamazaki T, Leung WY, Cain BD, Ostrov DA, Thorsness PE, Terada N.
PLoS One. 2011 Apr 21;6(4):e19250.
PMID: 21532989 [PubMed - in process]
Free PMC Article. Free full text. Related citations
- DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer.
Jaiswal AS, Banerjee S, Aneja R, Sarkar FH, Ostrov DA, Narayan S.
PLoS One. 2011 Feb 2;6(2):e16691.
PMID: 21311763 [PubMed - in process]
Free PMC Article. Free full text. Related citations
- Crystallization and preliminary X-ray analysis of the human long myosin light-chain kinase 1-specific domain IgCAM3.
Graham WV, Magis AT, Bailey KM, Turner JR, Ostrov DA.
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Feb 1;67(Pt 2):221-3. Epub 2011 Jan 22.
PMID: 21301090 [PubMed - indexed for MEDLINE]
Related citations
Find out more about the Ostrov lab:
General webpage:
http://www.med.ufl.edu/IDP/BMB/bmbfacultypages/dostrov.html
Cancer:
http://www.research.ufl.edu/publications/explore/past/summer2008/story_3/index.html
Hypertension/heart disease:
http://news.ufl.edu/2008/05/01/heart-effects/
http://news.ufl.edu/2008/05/01/ace/
http://www.gainesville.com/article/20080623/NEWS/806230306
http://www.genengnews.com/genCasts.aspx?id=213
http://www.drugdiscoverynews.com/index.php?newsarticle=2215
Immune system:
http://news.ufl.edu/2006/10/03/immune/
http://news.health.ufl.edu/2006/6580/colleges/college-of-medicine/tiny-tampa-bay-fish-key-to-evolution-of-immune-system/
http://www.underwatertimes.com/news.php?article_id=83410560791
Drug Discovery:
http://my.ufscc.ufl.edu/memarea/sbdd/index.htm
Teaching:
02/15/2012 GMS 6140 - Principles of Immunology (4 credits)