Publications

Song, S, Embury, J, Laipis, PJ, Berns, KI, Crawford, JM, Flotte, TR. Stable therapeutic serum levels of human alpha-1 antitrypsin (AAT) after portal vein injection of recombinant adeno-associated virus (rAAV) vectors. Gene Therapy, 8 (17): 1299-1306, 2001.

Donsante, A, Vogler, C, Muzyczka, N, Crawford, JM, Barker, J, Flotte, T, Campbell-Thompson, M, Daly, T, Sands, MS. Observed incidence of tumorigenesis in long-term rodent studies of rAAV vectors. Gene Therapy, 8 (17): 1343-1346, 2001.

Goudy, KS, S Song, C. Wasserfall, C Zhang, J Cross, M Kapturczak, A Muir, M Powers, MS Jorgensen, M Campbell-Thompson, JM Crawford, TM Ellis, TR Flotte, MA Atkinson. Adeno-associated virus vector mediated interleukin-10 gene delivery prevents type 1 diabetes in NOD mice. Proc Nat Acad Sci, 98: 13913-13918, 2001. PDF

Kapturczak, M, S. Zolotukhin, J. Cross, A. Pileggi, R.D. Molano, M. Jorgensen, B. Byrne, T. Flotte, T. Ellis, L. Inverardi, C. Ricordi, H. Nick, M. Atkinson, A. Agarwal. Transduction of human and mouse pancreatic islet cells using a bicistronic recombinant adeno-associated viral vector. Mol Therapy 5:154-161, 2002.

Zhang, YC, Molano, RD, Pileggi, A, Powers, M, Cross, J, Wasserfall, C, Scott-Jorgensen, M, Campbell-Thompson, M, Crawford, JM, Flotte, T, Ellis, TM, Ricordi, C, Atkinson, MA, Inverardi, L. Adeno-associated virus-mediated transduction of islets with interleukin-4 results in impaired function in a model of syngeneic marginal islet mass transplantation. Transplantation, 74:1184-1186, 2002.

Song, S, Scott-Jorgensen, M, Wang, J, Poirier, A, Crawford, J, Campbell-Thompson, M, Flotte, TR. Intramuscular administration of recombinant adeno-associated virus 2-1 antitrypsin (rAAV-SERPINA1) vectors in a nonhuman primate model: safety and immunologic aspects. Mol Therapy, 6:329-335, 2002.

Sautin, YY; Jorgensen, M; Petersen, BE; Saulnier-Blache, JS; Crawford, JM; Svetlov, SI. Hepatic oval (stem) cell expression of endothelial differentiation gene receptors for lysophosphatidic acid in mouse chronic liver injury. J Hematotherapy and Stem Cell Research, 11 (4): 643-649, 2002.

Zhang, YC, A. Pileggi, A. Agarwal, R. D. Molano, M. Powers, T. Brusko, C. Wasserfall, K. Goudy, E. Zahr, R. Poggioli, M. Scott-Jorgensen, M. Campbell-Thompson, J.M. Crawford, H. Nick, T. Flotte, T.M. Ellis, C. Ricordi, L. Inverardi, and M.A. Atkinson. Adeno-Associated Virus-Mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice. Diabetes 52: 708-716, 2003. PDF

Shklyaev, S, Aslanidi G, Tennant M, Prima V, Kohlbrenner E, Kroutov V, Sautin Y, Campbell-Thompson M, Crawford J, Shek E, Scarpace P, and Zolotukhin S. Sustained rAAV-Mediated Peripheral Expression of Transgene Adiponectin Offsets the Development of Diet-Induced Obesity in Sprague-Dawley Rats. Proc Nat Acad Sci 100 (24):14217-14222, 2003. PDF

Goudy, KS, Burkhardt, BR, Wasserfall, C, Song, S, Campbell-Thompson, M, Brusko, T, Powers, MA, Clare-Salzler, MJ, Sobel, ES, Ellis, TM, Flotte, TR, Atkinson, MA. Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type I diabetes in nonobese diabetic mice in a dose-dependent fashion. J Immunology, 2271-2278, 2003. PDF

Lu, Y., H. Dang, B. Middleton, Z. Zhang, l. Washburn, M. Campbell-Thompson, M. A. Atkinson, S. S. Gambhir, J. Tian, and D. L. Kaufman. Biomuninescent monitoring of islet graft survival after transplantation. Mol Therapy, 9 (3): 428-436, 2004. PDF

Zhang, C. , M. Powers, C. Wasserfall, T. Brusko, S. Song, T. Flotte, R. Snyder, M. Potter, M. Scott-Jorgensen, M. Campbell-Thompson, J. M. Crawford, HS Nick, A Agarwal, .T. M. Ellis, M.A. Atkinson. Immunity to adeno-associated virus serotype 2 delivered transgenes imparted by genetic predisposition to autoimmunity. Gene Therapy, 11(3):233-40, 2004. PDF

Chen S, Kapturczak MH, Wasserfall C, Glushakova OY, Campbell-Thompson M, Deshane JS, Joseph R, Cruz PE, Hauswirth WW, Madsen KM, Croker BP, Berns KI, Atkinson MA, Flotte TR, Tisher CC, Agarwal A. Interleukin 10 attenuates neointimal proliferation and inflammation in aortic allografts by a heme oxygenase-dependent pathway. Proc Nat Acad Sciences, epub May 6, 2005. PDF

Chen, S, M. Kapturczak, C. Wasserfall, O.Y. Glushakova, L. Zhang, P. Cruz, M. Campbell-Thompson, W.W. Hauswirth, K.I. Berns, K.M. Madsen, B.P. Croker, M.A. Atkinson, T.R. Flotte, C. C. Tisher, A. Agarwal. Efficient transduction of vascular endothelial cells with recombinant adeno-associated virus serotype 1 and 5 vectors. Human Gene Therapy, in press, 2005.

Loiler SA, Tang Q, Clarke T, Campbell-Thompson ML, Chiodo V, Hauswirth W, Cruz P, Perret-Gentil M, Atkinson MA. Localized Gene Expression Following Administration of Adeno-associated Viral Vectors via Pancreatic Ducts. Mol Ther. 2005 Jun 22; [Epub].

Zander, DS, Baz, MA, Cogle, CR, Visner, GA, Theise, ND, Crawford, JM. Bone marrow-derived stem-cell repopulation contributes minimally to the type II pneumocyte pool in transplanted human lungs. Transplantation 80:206-212, 2005. PDF

Zhang, Y Clare; Pileggi, Antonello; Molano, R Damaris; Wasserfall, Clive; Campbell-Thompson, Martha; Ricordi, Camillo; Atkinson, Mark A.; Inverardi, Luca. Systemic Overexpression of Interleukin-10 Fails to Protect Allogeneic Islet Transplants in Nonobese Diabetic Mice. Transplantation 80(4):530-533, 2005.

Conlon TJ , Cossette T, Erger K, Choi YK, Clarke T, Scott-Jorgensen M, Song S, Campbell-Thompson M, Crawford J, Flotte TR. Efficient Hepatic Delivery and Expression from a Recombinant Adeno-associated Virus 8 Pseudotyped alpha1-Antitrypsin Vector. Mol Ther. 2005 Aug 4; [Epub ahead of print].