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Publications:

Selected Peer-Reviewed Publications (in reverse order)

1. Yang, F., Li, Y., Braylan, R.C, Hunger, S.P., and Yang, L.J. (2006). Pediatric T-Cell Post-Transplant Lymphoproliferative Disorder after Solid Organ Transplantation. Pediatric Blood & Cancer in press

2. Yang, L.J. (2006). Liver Stem Cells Derived Surrogates for Treatment of Type 1 Diabetes. Autoimmunity Reviews. July;5(6):409-413

3. Tang, D.Q., Cao, L.Z., Li, S.W., Farag, C., Chang, L.J. & Yang, L.J. (2006). Role of Pax4 in Pdx1-VP16 mediated liver-to-endocrine pancreas transdifferentiation. Laboratory Investigation. Aug;86(8):829-41

4. Tang DQ, Lu S, Sun YP, Rodriguez E, Chou W, Yang C, Cao LZ, Chang L.J, & Yang, L.J.(2006). Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors. Laboratory Investigation. Jan;86(1):83-93

5. Xiong, C, Xie C.Q., Zhang, L, Zhang, J., Xu, K., Fu, M., Thompson, WE, Yang, L.J., & Chen, YE. (2005). Derivation of adipocytes from human embryonic stem cells. Stem Cell and Development. Dec;14(6):671-675

6. Chen, X, Tang, D.Q., Xie, C.Q., Thompson, W.E., Chang, L.J, Chen, Y.E, & Yang, L.J. (2005) .Genetic Engineering of Human Embryonic Stem Cells with Lentiviral Vectors. Stem Cell and Development. Aug; 14:367-377

7. Peck, A.B., Petersen, B., Ramiya, V. & Yang, L.J. (2005). The many faces of adult stem cellderived, in vitro-generated insulin-producing islet-like cells for the treatment of type 1 diabetes. In: Progress in Stem Cell Research Ed: Markino M. Nova Science Publishers, Inc., New York

8. Cao, L.Z., Tang, D.Q., Li, S.W., Horb, M.A. and Yang, L.J. (2004). External factors are necessary for Pdx-1 transfected hepatic cells to transdifferentiate into functional pancreatic endocrine insulin-producing cells. Diabetes. 53(12):3168-3178

9. Tang, D.Q., Cao, L.Z., Burkhardt, B.R., Xia, C.Q., Litherland, S.A., Atkinson, M.A., and Yang, L.J. (2004) In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes. 53(7):1721-32

10. Yuan, C., Douglas, V., Luchetta, G., Ahrens, K., Braylan, R. and Yang, L.J. (2004). Drag5-based cell cycle analysis of cell subpopulations discriminated by surface antigens and light scatter in hematopoietic tissue. Flow Cytometry, 58B:47-52

11. Li, S.W., Tang, D.Q., Ahrens, KP, She, J.X., Braylan, R.C., Yang, L.J. (2003) All-trans-retinoic acid induces CD52 expression in acute promyelocytic leukemia. Blood. 101(5):1977-80.

12. Yang, L.J., Zhao, H.S., Li, S.W., Collins, and. She, J.X. (2003). Gene expression patterns of retinoid acid-induced granulocytic differentiation of acute promyelocytic leukemic cells. J. Molecular Diagnostics. 5(4):212-221

13. Yang, L.J., Li, S.W., Hatch, H., Ahrens, K., Petersen, B.E. & Peck, A.B. (2002). In vitro transdifferentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Proc Natl Acad Sci U S A. 99: 8078-8083

14. . Maloney, J.A., Tsygankova, O.M., Yang, L.J., Li, Q.Y., Szot, A., Baysal, K., and Williamson, J.R. (1999). Activation of ERK by Ca2+ store depletion in rat liver epithelial cells. Am J Physiol (Cell Physiol ) 276: C221-C230

15. Yang, L.J., Guo, Y.L., Maloney, J. A., & Williamson, L.R. (1999). Angiotensin II Regulation of Extracellular Signal-regulated Protein Kinase in Rat Liver Epithelial WB cells. Biochemical Pharmacology, 57: 425-432

16. Guo, Y.L., Kang, B., Yang, L.J. and Williamson, J. R. (1999) Tumor necrosis factor- alpha and ceramide induce cell death through different mechanisms in rat mesangial cells. Am. J. Physiology, 276 (Renal Physiol.) 45: F390-F397

17. Guo, Y.L., Baysal,K., Kang, B., Yang, L.J., and Williamson, J.R. (1998) Correlation between Sustained c-Jun N-terminal Protein Kinase Activation and Apoptosis Induced by Tumor Necrosis Factor-alpha in Rat Mesangial Cells. J. Biol. Chem., 273: 4027-4034

18. Maloney, J.A., Tsygankova, O., Szot, A., Yang, L.J., Li, Q.Y., Williamson, J. R. (1998)Differential translocation of protein kinase C isozymes by phorbol esters, EGF, and ANG II in rat liver WB cells. Am J Physiol (Cell Physiol) 274: C974-C982

19. Pei, Z.D., Maloney, J.A., Yang, L.J., and Williamson, J.R. (1997). A new function for phospholipase C-γ1: Coupling to the adaptor protein GRB2. Arch. Biol. & Biophys., 345:103-110

20. Pei, Z. D., Yang, L. J., and Williamson, J. R. (1996) Phospholipase C-γ1 binds to actincytoskeleton via its C-terminal SH2 domain in vitro. Biochem. Biophys. Res. Commu., 228: 802-806

21. Yang, L.J., Rhee, S.G. and Williamson, J. R. (1994). Epidermal growth factor- induced activation and translocation of phospholipase C--γ to the cytoskeleton in rat hepatocytes. J. Biol. Chem., 269: 7156-7162

22. Baffy, G., Yang, L.J., Raj, S., Manning, D.R. and Williamson, J. R. (1994) G-protein coupling to the thrombin receptors in Chinese hamster lung fibroblasts. J. Biol. Chem., 269:8483-8487

23. Baffy, G., Yang, L.J., Wolf, B.A., and Williamson, J. R. (1993) G-protein specificity in signaling pathways that mobilize calcium in the insulin-secreting - TC3 cells. Diabetes. 42: 1878-1882 PMID: 8243834

24. Yang, L.J., Camoratto, A.M, Baffy, G., Raj, S., Manning, D.R. and Williamson, J.R. (1993) Epidermal growth factor-mediated signaling of Gi-protein to activation of phospholipases in cultured rat hepatocytes. J. Biol. Chem. 268: 3739-3746

25. Baffy,G., Yang, L.J., Michalopoulos, G.K. and Williamson, J.R. (1992) Hepatocyte growth factor induces calcium mobilization and inositol phosphate production in rat hepatocyes. J. Cell Physio. 153: 332-339 PMID: 1429853

26. Hansen,C.A., Yang, L.J. and Williamson, J.R. (1991) Mechanisms of receptor- mediated Ca2+ signaling in rat hepatocytes. J. Biol. Chem. 266:18573-18579

27. Yang, L.J., Baffy,G., Rhee,S.G., Manning, D., Hansen, C.A. and Williamson, J.R. (1991 Pertussis toxin-sensitive Gi-protein involvement in epidermal growth factor-induced activation of phospholipase C-r in rat hepatocytes. J. Biol. Chem. 266:22451-2245