Saeed
R. Khan, Ph.D
Professor
Director, Center for the Study of Lithiasis
and Pathological Calcification
|
|
Dept. of Pathology,
Immunology and Laboratory Medicine
University of Florida College
of Medicine
P.O. Box 100275
Gainesville, FL 32610-0275
Office Location and Express
Mail address:
Dept. of Pathology, Immunology
and Laboratory Medicine
University of Florida College
of Medicine
JHMHSC D6-17
1600 SW Archer Road
Gainesville, FL 32610-0275
Office: (352) 392-3574
Fax: (352) 392-8177, (352)
846-0155
Lab: (352) 265-0072
Email: khan@pathology.ufl.edu |
Primary Area of Research:
My laboratory is involved in examining all aspects of the Kidney Stone Disease
using in vitro tissue culture and in vivo laboratory rat models.
During development of the disease urinary oxalate is increased and
renal epithelial cells come in contact with abnormally high levels
of oxalate and calcium oxalate crystals resulting in localized injury
and inflammation. Expression of immediate early genes is induced.
Production of urinary macromolecules such as osteopontin and bikunin
is increased. Cells are injured. Some go through necrosis and others
become apoptotic. Crystal binding to renal epithelial cells is increased.
There is evidence of oxidative stress and lipid peroxidation of
cell membranes. Dead cells are sloughed off their basement membranes.
Cell membrane fragments are released into the urine where they can
promote further crystallization. Aggregation and retention of crystals
in the renal tubules initiate the stone formation. There is upregulation
and increased production of Monocyte-chemoattractant protein-1,
which attracts inflammatory cells to the renal interstitium. Vitamin
E and citrate appear to reduce crystal-induced oxidative stress
and crystal deposition in the kidneys.
Related
Links:
|
