Marguerite Hatch, B.Sc., PhD
Associate Professor
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Dept. of Pathology, Immunology and Laboratory Medicine |
Primary Area of Research:
My general interests are focused on the mechanisms and control of electrolyte and solute transport across epithelial membranes. In particular, I am interested in transport mechanisms for the oxalate anion across intestinal and renal epithelial in the context of calcium oxalate kidney stone disease and Primary Hyperoxaluria.
Current investigations in my laboratory are focused on several anion exchangers in the SLC26A gene family that are involved in epithelial oxalate transport. Using a variety of transport physiology and molecular biology approaches and studies that include whole animal (mouse knockout models) and tissue (intestine and kidney) in addition to cell culture studies, we are evaluating the contribution of specific transport proteins to epithelial movements of oxalate. My interest is also focused on the physiological interaction between the gut-resident Oxalobacter formigenes and the enterocyte which results in alterations of intestinal oxalate transport and enteric elimination of oxalate leading to reduced renal excretion of this stone-forming compound.
Related Links:
http://www.ohf.org/
http://www.pathology.ufl.edu/~freel/