Bryon Petersen

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Publications:

 
 
        1. Primer on Stem Cells, Part I: Stem Cell Biology, Christopher R. Cogle, Ronald C. Sanders, Edward W. Scott, and Bryon E. Petersen in press Mayo Clinic Proceedings.
        2. Primer on Stem Cells, Part II: Ethical and Regulatory Issues. Christopher R. Cogle, Steven M. Guthrie, Bill Allen, Edward W. Scott and Bryon E. Petersen in press Mayo Clinic Proceedings.
        3. ATP Cassette transporter gene expression in rat liver progenitor cells. Jenny E. Ros1, Tania AD Roskams2, Mariska Geuken1, Rick Havinga1, Patrick Splinter3, Bryon E. Petersen4, Nicholas F. LaRusso3, Han Moshage1, Folkert Kuipers1, Klaas Nico Faber1, Michael Müller5, and Peter L.M. Jansen1. Gut in press
        4. Neural Trans-differentiation Potential of Hepatic Oval Cells in the Neonatal Mouse Brain. Jie Deng1, Eric D. Laywell2, Dennis A. Steindler2,3 , Bryon E. Petersen1,3, in press Experimental Neurology.
        5. Mouse Hepatic Oval Cells Express the Hematopoietic Stem Cell Markers Sca-1 and CD-34. Bryon E. Petersena,*1, Brian Grossbarda, Heather Hatcha, Edward Scottb1. (2003) Hepatology, 37(3): 632-640.
        6. Hepatic oval "stem" cell in liver regeneration. Seh-Hoon OH, Heather M. Hatch, and Bryon E. Petersen. (2002) Seminars in Cell and Developmental Biology, 13: 405-409.
        7. Stem Cells in Adult Tissues Sharon C. Presnell , Bryon Petersen and Mohammad Heidaran. (2002) Seminars in Cell and Developmental Biology, 13: 369-376.
        8. SDF-1/CXCR4: A Possible Mechanism for Bone Marrow Derived Hepatic Oval Cell Recruitment to the Rat Liver. Hatch H, Zhang D, Jorgensen MS. and Petersen BE. (2002) Cloning and Stem Cells 4(4): 339-352.
        9. In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells. Lijun Yang, Shiwu Li, Heather Hatch, Kim Ahrens, Janet G. Cornelius, Ammon B. Peck and Bryon E. Petersen. PNAS 99: 8078.
        10. Bone Marrow Cells Adopt Phenotype of Other Cells by Spontaneous Cell Fusion. Naohiro Terada, Takashi Hamazaki, Masahiro Oka, Masanori Hoki, Diana M. Mastalerz, Yuka Nakano, Edwin M. Meyer, Laurence Morel, Bryon E. Petersen and Edward W. Scott. (2002) Nature 416: 542.
        11. The processing and utilization of Hepatocyte Growth Factor/Scatter Factor following partial hepatectomy in the rat. Pediaditakis P, Lopez-Talavera JC, Petersen BE, Monga SPS, and Michalopolos GK. Hepatology 34(4): 688.
        12. Hepatic oval (stem) cell expression of EDG receptors for lysophosphatidic acid in mouse chronic liver injury. Yuri Y. Sautin, Marda Jorgensen, , Jean S. Saulnier-Blache, James M. Crawford, Stanislav I. Svetlov, and Bryon Petersen. In press. Journal of Hematotherapy & Stem Cell Research.
        13. Stem Cells: A Journey into a New Frontier. Petersen BE and Terada N. Journal of Nephrology 12(8): 1773.
        14. Hepatic Stem Cells: Coming full circle. Petersen BE. Journal Blood Cells, Molecules and Disease 27(3) May/June; 590.
        15. Adrenergic stimulation of Hepatocyte Growth Factor expression. Broten J., Michalopoulos GK. Petersen BE. and Cruise J. BBRC. 262(1): 76. 
        16. Hepatocyte growth factor (HGF) and receptor (c-met) in normal and malignant astrocytic cells. Welsh WC., Kornblith PL., Michlaopoulos GK., Petersen BE., Beedle A., Gollin SM. and Golgfarb RH. Anticancer Research.19(3A): 165 
        17. Growth factor signal transduction immediately following two-thirds partial hepatectomy in the rat. Stolz D-B., Mars WM., Petersen BE., Kim T-Y., and Michalopoulos GK.  (1999). Cancer Research. (59): 3954-3960. 
        18. Bone marrow as a potential source for hepatic oval cells. Petersen BE., Bowen WC., Mars   WM., Patrene KD., Boggs SS., Sullivan AK., Greenberger JS., and Goff JP.(1999)  Science 284: 1168-1170. 
        19. Hepatic oval cell activation in response to injury following chemically induced periportal or  pericentral damage. Petersen BE., Zajac VF and Michalopoulos GK. (1998) Hepatology.  27 (4): 1030-1038. 
        20. Hepatic oval cells express the hematopoietic stem cell marker Thy-1 in the rat. Petersen   BE., Goff JP., Greenberger JS and Michalopoulos GK. (1998) Hepatology. 27(2): 433-445 
        21. Bile ductular damage induced by Methylene Dianiline inhibits oval cell activation. Petersen BE.,  Zajac VF. and Michalopoulos GK. (1997) American Journal of Pathology 151(4): 905-910 
        22. Extracellular matrix remodeling at the early stages of liver regeneration. Kim T-Y., Mars WM.,  Stolz DB., Petersen BE and Michalpoulos GK.(1997) Hepatology 26(4): 896-904. 
        23. Expression of HGF and cMet in the developing and adult brain. Achim CL., Katyal S.,   Wiley CA., Shiratori M., Wang G., Oshika E., Petersen BE., Li J-M. and   Michalopoulos GK. (1997) Development Brain Research 102(2): 299-303 
        24. Population expansion, clonal growth, and specific differentiation patterns in primary cultures of  hepatocytes induced by HGF/SF, EGF and TGF-? in a chemically defined (HGM) medium.  Block GD., Locker J., Bowen WC., Petersen BE., Katyal S., Strom SC., Riley T., Howard  TA and Michalopoulos GK. (1996) Journal of Cell Biology 132: 1133-1149. 
        25. Synergistic effects of hepatocyte growth factor on human cord blood CD34+ progenitor cells are  the result of c-mat receptor expression on the stem cell. Goff JP., Shields DS., Petersen  BE., Zajac VF., Michalopoulos GK and Greenberger JS. (1996) Stem Cell 14(5); 592-602. 
        26. Hepatic Stem Cells and Growth Factor Regulation in Liver Regeneration Following Toxic Injury.  Petersen BE. (1996) Doctoral Dissertation, University of Pittsburgh. 
        27. Hepatic Stem Cells, Hepatocyte Growth Factor (HGF) and its Receptor Regulation During Liver  Regeneration After Allyl Alcohol (AA) and Carbon Tetrachloride (CCl4) Injury. Petersen  BE. (1995) Master of Science Thesis, University of Pittsburgh. 
        28. Distinct morphological and mito-inhibitory effects induced by TGF-?1, HGF and EGF   on mouse, rat and human hepatocytes. Petersen BE., Yee CJ., Bowen W., Zarnegar R., and  Michalopoulos GK, (1994) Cell Bio and Tox 10: 219. 
        29. Expression and characterization of biologically active human hepatocyte growth factor   (HGF) by insect cell infected with HGF-recombinant baclovirus. Yee CJ., DeFrances  MC., Bell A., Bowen W., Petersen BE., Michalopoulos GK., and Zarnegar R.   (1993) Biochem 32 (31): 7922. 
        30. Localization of Hepatocyte Growth Factor (HGF) gene one human chromosome 7. R. Zarnegar,  BE. Petersen, M.C. DeFrances, G.K. Michalopoulos. (1992) Genomic Jan. 12 : 147.
        31. Liver Response to Chronic injury induced by Allyl Alcohol or Carbon Tetrachloride.  Petersen BE.,Zajac VF., Strom SC., Nomoto M. and Michalopoulos GK. resubmitted to Journal of Pathology. 
        32. Methylene Diailine toxicity as a potential tool to study bile duct regeneration in wild type and IL-6  knockout mice. Petersen BE., Sakamoto T., Demetris AJ. and Michalopoulos GK. In  preparation for the journal American Journal of Pathology. 
        33. Hepatic responses to acute injury following chemically induced periportal or pericentical  damage. Petersen BE., Zajac VF. and Michalopoulos GK. In preparation for Hepatology. 
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  Book Chapters:
    • Effects of Hepatocyte Growth Factor and IL-11 on Human Cord Blood CD34+ Progenitor Cells. Goff JP., Shields DS., Petersen BE., Michalopoulos GK. and Greenberger JS. In:Proceedings of Keystone Symposium; Molecular and Cellular Biology: The hematopoietic microenvironment. Eds Greenbeger JS and Keadding AM. Cambridge University Press.
    • Liver Stem Cells.  Petersen BE, Hatch H in Methods of Tissue Engineering.  Eds.  Atala A, Lanza P.  Chapter 35, Academic Press. 2002.
    • Turning Blood into Liver: Theise ND and Petersen BE. In Stem Cell Therapy for Autoimmune Disease. Ed. Richard Burt and Alberto Marmont. Landes Bioscience/Eurekah Press. Chapter 4.

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Abstracts:
        1. Potential Neural Trans-differentiation of Hepatic Oval Cells in Vitro and in Vivo. Jie Deng, Eric Laywell, Valery Kukekov, Dennis Steindler and Bryon E. Petersen. 32nd Annual Meeting of the Society for Neuroscience. November 2-7, 2002. Orlando, FL.
        2. Bone marrow as a potential source for hepatic oval cells. Petersen BE., Bowen WC., Mars WM., Patrene KD., Boggs SS., Sullivan AK. and Greenberger JS., Goff JP. (1999)  Experimental Biology, FASEB, American Society for Investigative Pathology, Late  Breaking Poster Session. April 17-21.
        3. Liver regeneration after necrosis induced by Allyl Alcohol and Carbon Tetrachloride. Tsamandas AC., Petersen BE., Felekouras ES., Sigala F., Bastounis H., Papalabros E.  and  Michalopoulos GK.(1999) United States and Canadian Academy of Pathology,   San Francisco, CA, March 20-26, 1999. Lab. Invest 79(1): 168A, #985. 
        4. Bile duct regeneration following severe toxic injury from Methylene Dianaline. Petersen BE.,  Sakamoto T., Demetris AJ. and Michalopoulos GK. (1998) FASEB Summer Research  Conference, Mechanisms of liver growth and differentiation in health and disease.  Snowmass CO, July 11-16. (Oral Presentation) 
        5. Thy-1+ sorted hepatic oval cells in culture maintain oval cell phenotypic markers. Petersen BE.,  Goff JP., Boewn WC., Sheilds DS., Greenberger JS., and Michalopoulos GK. (1998)  Experimental Biology, American Society for Investigative Pathology, San Francisco, April  18-22. (Poster Discussion) 
        6. Partial purification and characterization of Sundance Kid (SK): A protein binding to HNF-4   specific binding site. Runge D., Runge DM., Bowen WC., Petersen BE., Stolz DB.   and Michalopoulos GK.(1998) Normal and Malignant Liver Cell Growth, Falk  Workshop. January 29-30, Halle, Germany. 
        7. Partial reinigung und charakterisierung von Sundance Kid: Ein protein, das eine HNF-4  spezifische bindesequenz erkennt. Runge D., Runge DM., Bowen WC., Petersen BE.,  Stolz DB. and Michalopoulos GK.(1998). German Association for the Study of Liver.   January 30-31, Halle, Germany. 
        8. Growth factor signal transduction in rat liver immediately following partial hepatectomy.  StolzDB., Petersen BE., Mars WM., Kim T-H. and Michalopoulos GK. (1997) 37th ASCB  Annual meeting. Mole Bio of the Cell, vol 8 number 1434, page 248a 
        9. Hepatic response to chemically induced periportal and pericentral damage. Petersen BE., Zajac  VF., Strom SC., Nomot M. and Michalopoulos GK. (1997) Eighty-seventh Annual Meeting  of the American Association for Cancer Research April 12-16 (poster session). 
        10. c-Met receptor is expressed on human cord blood CD34+Thy1+Lin- stem cells and is up- regulated in CD34+ progenitor cells in response to IL-11. Goff JP., Sheilds DS., Petersen  BE., Zajac VF., Michalopoulos GK. And Greenberger JS. (1996) Keystone Symposium;  Molecular and Cellular Biology: The hematopoietic microenvironment Taos NM, February  10-16. 
        11. Hepatic oval cell activation disrupted when bile duct destruction occurs following Methylene  Dianiline. Petersen BE., Zajac VF. and Michalopoulos GK. (1996) American Society for  Investigative Pathology, August 4-9. 
        12. Hepatic oval cells express the hematopoietic stem cell marker Thy1. Petersen BE., Goff JP.,  Greenberger JS. and Michalopoulos GK.(1996) FASEB Summer Research Conference,  Snowmass CO, August 4-9. 
        13. Hepatocyte Growth Factor (HGF) and Transforming Growth Factor alpha (TGF-?)  independently  promote conversion of hepatocytes to hepatoblasts in long term in vitro growth conditions.  Michalopoulos GK., Block GD., Bowen W., Locker J., and Petersen BE. (1995) Eighty- sixth Annual Meeting for the American Association for Cancer Research March 18-22  (poster session). 
        14. Hepatic stem cells, Hepatocyte Growth Factor (HGF) and its receptor MET regulation in the  regenerating liver after Allyl Alcohol (AA) and Carbon Tetrachloride (CCl4) poisoning.  Petersen BE. and Michalopoulos GK. (1995) FASEB J 9(4): 789. (poster discussion)
        15. The presence of urokinase and its receptor in primary rat hepatocyte cultures Mars W., Petersen  BE., Stolz D., and Michalopoulos GK. (1995) FASEB J 9(4): 456. (poster session) 
        16. Regulation of gene expression in mature hepatocytes undergoing sustained proliferation in culture.  Block JD., Petersen BE., Bowen W., Locker J., and Michalopoulos GK. (1995) Meetings  of the AGA, AASLD at Digestive Disease Week May 14-17 (poster session).  Sustained cultures with collagen gel bilayers with creation of bile ductular cells with stimulation  of hepatocytes by defined media, HGF and EGF. Riley TR., Bowen W., Petersen BE.,  Block GD., Locker J., and Michalopoulos GK. GK. (1995) Meetings of the AGA, AASLD  at Digestive Disease Week May 14-17 (poster session). 
        17. Hepatocyte Growth Factor (HGF) and Carcinogenesis. Moghul A., Alacron W., Petersen BE.,  Bell A., DeFrances MC., and Zarnegar R. (1993) FASEB J 7(4): 637. 
        18. The effects of HGF, EGF, and TGF-?1 on DNA synthesis and morphology of mouse, rat and  human hepatocytes. Petersen, BE., Zarnegar R., Bowen W., and Michalopoulos GK. (1993)  Eighty-fourth Annual Meeting of the American Association for Cancer Research May  19-22 (poster session) 
        19. Generation of transgenic mice carrying human HGF cDNA. Zarnegar, R., DeFrances, M.C.,  Petersen, BE. and Michalopoulos, G. (1992) Eighty-third Annual Meeting of the American  Association for Cancer Research May 20-23 (poster session).
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