Bryon
Petersen, PhD
Associate Professor
|
|
Dept.
of Pathology, Immunology and Laboratory Medicine
University of
Florida College of Medicine
P.O. Box
100275
Gainesville,
FL 32610-0275
Office
Location and Express Mail address:
Dept. of Pathology,
Immunology and Laboratory Medicine
University of
Florida
College of
Medicine
JHMHSC M-641H
1600 SW
Archer Road Gainesville, FL 32610-0275
Office: (352)
392-6261
Fax: (352)
392-6249
Senior
Secretary: Mandy Nevills: (352) 392-2886
Email: petersen@pathology.ufl.edu
|
Primary Area of
Research:
Currently my lab
focuses on liver growth, development and regeneration under normal and
carcinogeneic conditions. Compensatory hyperplasia of the liver, most
often referred to as liver regeneration, takes place after the
occurrence of mild or severe injury, as resulting from a surgical
partial hepatectomy or the widespread injury caused by hepatotoxic
agents like carbon tetrachloride (CCl4) or acetaminophen. We are
currently studying the molecular signals involved in the regenerative
process.
A more focused
aspect of our research deals with the hepatic oval “stem” cell and
their involvement in the hepatic architecture as it pertains to the
regenerative process. Hepatic oval “stem” cells are a small
sub-population of cells found in the liver when hepatocyte
proliferation is impeded and followed by some type of hepatic injury.
The hepatic stem cells can be stimulated to proliferate using a
2-AAF/hepatic injury (i.e. CCl4, PHx) protocol. These cells are
believed to be bipotential, able to differentiate into hepatocytes and
bile ductular cells. We have recently shown that the hepatic oval cell
are derived from an extra-hepatic source, see Science 284: 1168-1170.
We are investigating the pathways involved in the recruitment of bone
marrow derived to the liver in both in vivo and in vitro conditions. In
addition, we are exploring the use of a highly pure population of oval
cells to ascertain their potential for gene/cell therapy techniques.
Laboratory Personnel:
Post-docs:
Degree Granting Institution:
Major Project:
Seh-hoon Oh, Ph.D.
University
of Okayama, South Korea Adult Stem cell
trans-differentiation into Beta-like Cells
Liya Pi, Ph.D.
University of Florida, FL
CTGF involvement in liver
regeneration
Tom Shupe, Ph.D.
Albany
Medical College, NY
Stem cell involvement in HCC and
CCC development
Graduate
Students:
Donghang Zheng
Shanghai Medical University, China
SDF-1/CXCR4 pathway and liver regeneration
Susan Ellor
Rutgers University,
NJ
Gene
therapy approaches to hepatic disorders
Youngmi Jung
Seoul
National University, South Korea Somatostain
involvement in pancreatic/hepatic repair
Houda Darwiche
University of Florida, FL
Notch and Jagged signalling in stem cell differentiation
Jennifer M. LaPlante
Ohio Wesleyan University, OH
Wnt signalling in liver regeneration
Staff:
Alicia Brown
University of Illinois, IL
Laboratory Manager
UF Stem
Cell Program, Core Histology Laboratory: (located
in M641, MSB)
Marda Jorgensen, BS.
North Florida University,
FL
Director
Graduated Students and Fellows:
Sihyan Bae, MD.,
Ph.D.
Catholic University, South
Korea Mouse ES
cell differentiation into hepatic cells
Takahisa Fijikawa,
MD. Kyoto University, Japan
Mouse ES cell differentiation
into pancreatic cells
Jie Deng, Ph.D.
University of Florida, FL
Neurogenesis of hepatic and BM stem cells
Rafal Witek, Ph.D.
University of Florida, FL
Gene
therapy approaches to hepatic disorders
Samatha Fisher, BS
Unversity of
Florida, FL
Technician
Heather Hatch, MS
University of Florida, FL
Notch and Jagged signalling in stem cell differentiation
Related Links:
John Hopkins Presentation
|