William L. Clapp, MD
Associate Professor
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Dept. of Pathology, Immunology and Laboratory Medicine |
Currently Involved In:
My area of diagnostic expertise is renal pathology, which includes
the evaluation of renal biopsies from other institutions throughout
the Southeast. I am a working general surgical pathologist and also
have interests and responsibilities in ultrastructural pathology
and hematopathology.
My teaching interests and responsibilities include the cell and molecular biology of cancer and the directorship of the Renal Pathology Course for the UF medical students.
My research interests include both the underlying mechanisms and diagnostic aspects of renal development, as well as medical diseases and tumors of the kidney.
Administrative responsibilities include serving as Chief of Anatomic Pathology of the North Florida /South Georgia Veterans Health System and several committee memberships.
Related Links:
American Association for Cancer Research
International Society of Nephrology
Clinical Research Committee
Renal Pathology Society
Publications
- Pitcock JA, Brown B, Brooks B, Clapp WL, Brosius WL, Muirhead EE. Renomedullary deficiency in partial nephrectomy-salt hypertension. Hypertension 2: 281-290, 1980
- Schumacker HR, Clapp WL, Thomas WJ, Mandavia SG, Pitts LL, Holloway ML, Stass SA. Acute lymphoblastic leukemia:hand mirror variant. Arch Pathol Lab Med 104:134-136, 1980
- Clapp WL, Madsen KM, Verlander JW, Tisher CC. The intercalated cells of the rat inner medullary collecting duct. Kidney Int 31: 1080-1087, 1987
- Larsson L, Clapp WL, Park CH, Cannon JK, Tisher CC. Localization of acidic compartments in cells of isolated rabbit proximal convoluted tubules. Amer J Physiol 253: F95-F103, 1987
- Clapp WL, Park CH, Madsen KM, Tisher CC. Axial heterogeneity in the handling of albumin by the rabbit proximal tubule. Laboratory Invest 58: 549-558, 1988
- Madsen KM, Clapp WL, Verlander JW. Structure and function of the inner medullary collecting duct. Kidney Int 34: 441-454, 1988
- Clapp WL, Madsen KM, Verlander JW, Tisher CC. Morphologic heterogeneity of the rat inner medullary collecting duct. Laboratory Invest 60: 219-230, 1989
- Butt AG, Clapp WL, Frizzell RA. Potassium conductances in tracheal epithelium activated by secretion and cell swelling. Amer J Physiol 258: C630- C638, 1990
- Clapp WL, Abrahamson DR. Regulation of kidney organogenesis: Homeobox genes, growth factors and Wilms tumor. Current Opinion in Nephrology and Hypertension 2: 419-429, 1993
- Clapp WL, Bowman PP,Shaw GS,Patel P, Kone BC. Segmental localization of mRNAs encoding ? and ? isoforms of Na-K-ATPase in rat kidney using RT-PCR. Kidney Int 46: 627-638, 1994
- Mohaupt M, Elzie JL, Ahn KY, Clapp WL, Wilcox CS, Kone BC. Differential expression of mRNAs encoding two inducible nitric oxide synthases in rat kidney. Kidney Int 46: 653-665, 1994
- Ramos EL, Barri YM, Croker BP, Clapp WL, Peterson JC, Wilcox CS. Thromboxane synthase expression in renal transplant patients with rejection. Transplantation 59: 490-494, 1995
- Croker BP, Clapp WL, Kone BC, Peterson JC. Macrophages and chronic renal allograft nephropathy. Kidney Int 50 (Suppl. 57) S42-S49, 1996
- Wingo CS, Clapp WL. Proteinuria: Potential causes and approach to evaluation. Am J Med Sci 320: 188-194, 2000
- Scornik JC, Clapp WL, Patton PR, Van der Werf WJ, Hemming AW, Reed AI, Howard RJ. Prospective flow cytometry cross matching: Outcome of kidney transplants in patients known to be flow cytometry crossmatch positive. Transplantation 71: 1098-1102, 2001
- Iczkowski K, Katz, G, Zander D, Clapp WL. Malignant mesothelioma of tunica vaginalis testis: a fatal case with liver metastasis that lacks expression of WT1. J Urology 167: 645-646, 2002
- Ross EA, Batich CD, Clapp WL, Sallustio JE, Lee NC. Tissue adhesion to bioactive glass-coated silicone tubing in a rat model of PD catheters. Kidney International 63: 702-708, 2003
- Araya C, Clapp WL, Redman RS, Dharnidharka VR. Acute-onset hearing loss with renal failure: differential diagnosis. Am J Kidney Dis 47: 553-558, 2006
- Han KH, Croker BP, Clapp WL, Werner D, Kim J, Sahni M, Kim J, Kim HY, Handlogten ME, Weiner ID, Expression of the ammonium transporter, rh C Glycoprotein, in normal and neoplastic human kidney. J Amer Soc Nephrol 17: 2670-2779, 2006
- Cheng S, Clancy CJ, Nguyen KT, Clapp WL, Nguyen MH. A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole. Antimicrob Agents Chemother 51:1855-1858, 2007
- Kazory A, Clapp WL, Ejaz AA, Ross EA. Shortened hemofilter survival time due to lipid infusion in continuous renal replacement therapy. Nephron Clin Pract 108: 5-9, 2008
- Redman R, Shunkwiler SM, Harris NS, Kedar A, Clapp WL. Sebastian syndrome with abnormal platelet response to ristocetin. Lab Hematol 14: 19-23, 2008
- Stacy NI, Nabity MB, Hackendahl N, Buote M, Ward J, Ginn P, Vernau W, Clapp WL, Harvey JW. B-cell lymphoma with Mott cell differentiation in two young adult dogs. Vet Clin Pathol 38:113-120, 2009
- Harvey JW, Harr KE, Murphy D, Walsh MT, Nolan EC, Bonde RK, Pate MG, Deutsch CJ, Edwards HH, Clapp WL. Hematology of healthy Florida manatees (Tricechus manatus). Vet Clin Pathol 38:183-193, 2009
- Ross EA, Williams MJ, Hamazaki T, Terada N, Clapp WL, Adin C, Ellison GW, Jorgensen M, Batich CD. Embryonic stem cells proliferate and differentiate when seeded into kidney scaffolds. J Am Soc Nephrol 20:2338-2347, 2009
- Dana A-P, Ahmar CA, Clapp WL, Ross EA. A new form of myeloma 'kidney": Shortened hemofilter survival and implications for membrane filtration plasmapheresis. Clinical Nephrology 75: 120-124, 2011
- Jeung JA, Cao D, Selli BW, Clapp WL, Oliai BR, Parwani AV, Allan RW. Primary renal carcinoid tumors: evaluation of Pax-2 and Pax-8 expression with emphasis on novel immunohistochemical findings. Human Pathology (2011, in press)
Book Chapters
- Clapp WL, Tisher CC. Gross anatomy and development of the kidney. In: Renal Pathology, edited by Tisher CC, Brenner BM, Philadelphia: J. B. Lippincott Co, pp 67-89, 1989
- Clapp WL. Adult kidney. In: Histology for Pathologists, edited by Sternberg S, New York: Raven Press, pp 776-807, 1992
- Clapp WL, Tisher CC. Anatomie der Niere. In: Klinische Nephrologie. Handbuch fur Klinik und Praxis, edited by Franz HE, Risler T, Bavaria: Ecomed, pp 1-22, 1993
- Clapp WL, Abrahamson DR. Development and gross anatomy of the kidney. In: Renal Pathology, 2nd edition, edited by Tisher CC, Brenner BM, Philadelphia: J B Lippincott Co, pp 3- 59, 1994
- Mohaupt MG, Madsen KM, Wilcox CS, Clapp WL, Kone BC. Molecular characterization and localization of three nitric oxide synthase isoforms in rat kidney. In: The Biology of Nitric Oxide, Part 4, edited by Moncada S, Feelish R, Busse T, Higgs EA, New York, Portland Press, pp 137-141, 1995
- Abrahamson DR, Vanden Heuval GB, Clapp WL. Nephritogenic antigens in the glomerular basement membrane. In: Immunologic Renal Diseases, edited by Neilson EG, Couser WG, New York: Raven Press, pp 217-234, 1996
- Clapp WL, Croker BP. Adult Kidney. In: Histology for Pathologists, 2nd edition, edited by Sternberg S, New York: Raven Press, pp 799-834, 1997
- Clapp WL, Croker BP. Kidney. In: Histology for Pathologists, 3rd edition, edited by Mills, SE, Lippincott Williams & Wilkins, pp 839-907, 2007
- Clapp WL. Renal Anatomy In: Silva's Diagnostc Renal Pathology. Zhou XJ, Laszik Z, Nadasdy T, D'Agati VD, Silva FG, eds. New York, NY: Cambridge University Press: pp 1-46, 2009
- Clapp WL, Croker BP. Kidney. In: Histology for Pathologists, 4th edition, edited by Mills, SE, Lippincott Williams & Wilkins (2012, in preparation)
Abstracts
- Pitcock JA, Brown P, Brooks B, Brosius WL, Clapp WL, Muirhead EE. Partial-nephrectomy-salt hypertension. Fed Proc 36: 438, 1977
- Muirhead EE, Clapp WL, Pitcock JA, Brown P, Brosius WL. Renomedullary interstitial cell(RIC) damage and the evolution of salt dependent hypertension. Kidney Int 12: 505, 1977
- Muirhead EE, Pitcock JA, Clapp WL, Brooks B, Brown P. Renomedullary antihypertensive deficiency in partial nephrectomy-salt hypertension. Kidney Int 14: 699, 1978
- Pitcock JA, Brown P, Brooks B, Clapp WL, Muirhead EE. Renomedullary deficiency in partial nephrectomy-salt hypertension. Fed Proc 38: 1438, 1979
- Madsen KM, Clapp WL, Tisher CC. Intercalated cells are present in rat inner medullary collecting duct. Clin Res 33(2): 492, 1985
- Clapp WL, Park CH, Tisher CC. Axial heterogeneity in the tubular handling of protein in rabbit proximal tubule. Clin Res 34(2): 592, 1986
- Verlander J, Larsson L, Clapp WL, Madsen KM, Wingo C, Tisher CC. Localization of acidic compartments of rat outer medullary collecting duct (OMCD). Kidney Int 31: 417, 1987
- Clapp WL, Park CH, Tisher CC. Effect of monensin on morphology and function of the endosomal- lysosomal system in the proximal tubule. Clin Res 35(3): 544, 1987
- Clapp WL, Park CH, Tisher CC. Proximal tubular handling of protein: Axial heterogeneity. 10th International Congress of Nephrology, London, 1987
- Park CH, Clapp WL, Madsen KM, Tisher CC. Effects of monensin and chloroquine on morphology and function of the endosomal lysosomal system in the proximal tubule. 10th International Congress of Nephrology, London, 1987
- Clapp WL, Madsen KM, Verlander JW, Tisher CC. Structural heterogeneity along the rat inner medullary collecting duct. Kidney Int 33: 432, 1988
- Clapp WL, Bowman PR, Patel P, Kone BC. Localization of mRNAs encoding Na/K-ATPase subunit isoforms in rat kidney using RT-PCR. J Amer Soc Nephrol 3: 805, 1992
- Kone BC, Bowman PR, Patel P, Andaloro VJ, Guzman NJ, Clapp WL. Differential expression of the and isoforms of the Na/K-ATPase in cultured rat mesangial cells. J Amer Soc Nephrol 3: 811, 1992
- Ahn KY, Clapp WL, Zhang L, Bowman P, Madsen KM, Tisher CC, Kone BC. Cellular distribution of Na/K-ATPase isoforms in rat kidney. J Amer Soc Nephrol 4: 862, 1993
- Clapp WL, Rowald D, Smith J, Lopez C, Baker H. Identification of WT1- interacting proteins (WIPs). J Amer Soc Nephrol 7(9): A1721, 1996
- roker BP, Madsen KM, Corpier CL, Clapp WL, Massey JK. Macrophages and renal allograft failure. Banff International Conference on Transplantation Pathology, 1997
- Marcussen N, Croker BP, Clapp WL. Reproducibility of the Banff classification of chronic allograft nephropathy. Banff International Conference on Transplantation Pathology, 1997
- Clapp WL, Rowald D, Lopez C, Baker H. A novel protein that interacts with the WT1 protein. Amer Cancer Society (Florida Division) Annual Meeting,1997
- Corpier CL, Croker BP, Clapp WL, Massey KJ. Pathogenesis of chronic renal failure (CRF) in renal allografts. J Amer Soc Nephrol 8: A3159, 1997
- Ross EA, Batich CD, Clapp WL, Sallustio JE, Lee NC. Tissue adhesion to bioactive glass-coated silicone tubing in a rat model of PD catheters. J Amer Soc Nephrol 12: A1620, 2001
- Redman R, Harris NS, Clapp WL. Giant platelets and absent response to ristocetin on platelet aggregation: The need for electron microscopy. Modern Pathology 19 (Supp. 1) 340A, 2006 (USCAP Annual Meeting, 2006)
- Williams M, Batich C, Clapp W, Hamazaki T, Ellison G, Nao T, Ross E. Differentiation of murine embryonic stem cells in decellularized rat kidney scaffold. (Amer Soc Nephrol Annual Meeting, 2007)
- Gersch M, Heinig M, Clapp W, Rodriquez-Iturbe B, Johnson R. The immune response is required for the development of salt sensitive hypertension. (Amer Soc Nephrol Annual Meeting, 2007)
- Dana A-P, Ahmar CA, Clapp WL, Ross EA. A new form of myeloma 'kidney": Shortened hemofilter survival and implications for membrane filtration plasmapheresis. (National Kidney Foundation Meeting, 2010)
- Indahyung R, Shafiu M, Clapp W, Segal M. Cryoglobulinemic membranoproliferative glomerulonephritis in a patient with scleroderma and Sjogren syndrome. (National Kidney Foundation Meeting, 2010)
- Indahyung R, Ahmar C, Clapp W, Hsu S. The descriptive epidemiology of biopsy-proven primary glomerular diseases in adults from the University of Florida-Shands Hospital Registry over three decades (1979-2009) (American Society of Nephrology Annual Meeting, DEC 2010)
- Indahyung R, Ahmar C, Croker B, Clapp W, Hsu S. The descriptive epidemiology of biopsy-proven secondary glomerular diseases in adults from the University of Florida-Shands Hospital Registry over three decades (1979-2009) (American Society of Nephrology Annual Meeting, DEC 2010)
- Ross EA, Abrahamson DR, Clapp WL, Williams MJ, Hamazaki T, Batich C. Basement membrane remodeling and endothelial differentiation when mouse stem cells seeded into acellular rat kidney scaffolds. (American Society of Nephrology Annual Meeting, DEC 2011)
- Lin CS, Siebein KN, ClappWL. Application of electron microscopy and elemental spectral analysis in the diagnosis of argyria following colloidal silver ingestion. (American Society of Dermatopathology Annual Meeting, OCT 2011)