Nephrolithiasis

The Faculty of this specialty is currently focused on investigating the fundamental mechanisms responsible for the formation of kidney stones aimed primarily to better manage and eventually prevent kidney stone disease. As most kidney stones are composed of calcium oxalate, a concerted effort is to understand the patho-physiological aspects of high urinary excretion of oxalate, considered an important risk factor in the development of kidney stones. Drs. Hatch and Freel are investigating intestinal oxalate transport, while Dr. Peck is interested in examining the role of the gut inhabiting bacterium, Oxalobacter formigenes, in regulating oxalate homeostasis through catabolizing ingested oxalate. Lastly, Dr. Khan is examining the relationship between oxalate-induced oxidative stress and kidney stone-induced inflammation of the kidney.

Faculty:

• - Freel, PhD


• - Hatch, PhD


• - Khan, PhD


• - Peck, PhD