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Research Focus
The ability of the immune system to discriminate between that which should be destroyed (microbial
pathogens and cancer) from that which should not be destroyed (normal cells and tissues) is a
fundamental property of the vertebrate immune system. Our laboratory is interested in the structure
and function of molecules involved in immune recognition events. We use a combination of techniques
to address the structural, biochemical and functional properties of key proteins involved in the
adaptive immune response.
One of our major goals is to understand proteins involved in T cell recognition and costimulation
through high resolution x-ray structural determination. In addition, crystal
structures are utilized in a molecular docking strategy to design novel immunomodulatory therapeutics.
Functional assays of T cell recognition are employed to evaluate the capacity of compounds to induce
antigen specific tolerance.
>More Research Information...
Recent Events
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Christine Barnes wins summer fellowship from the American Cancer Society.
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New crystallography target (Allograft Inflammatory Factor) expressed and purified by Patrick Quint.
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New crystals and x-ray data of HKE2, a novel protein expressed in T cells.
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Welcome to the lab Jose Hernandez.
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