Sally Litherland Assistant Professor Department of Pathology, Immunology and Laboratory Medicine  University of Florida College of Medicine  Gainesville, Florida  Publications

Publications:

1. Xiang, Z., I. Pogozheva, N. Sorenson, A. Wilczynski, J. Holder, S. A. Litherland, W. Millard, H. Mosberg, C. Haskell-Luevano. 2007. Peptide and Small Molecules Rescue Functional Activity and Agonist Potency of Dysfunctional Human Melanocortin-4 Receptor Polymorphisms. Biochemistry. In press.

2. Davoodi-Semiromi, A., M. McDuffie, S. A. Litherland, and M. J. Clare-Salzler. 2007. Truncated pSTAT5B is associated with the Idd4 locus in NOD mice. Biochem Biophy Res Com. In press.

3. Ostrov, D.A., C.L. Barnes, L.E. Smith, S. Binns, T.M. Brusko, A. C. Brown, P.S. Quint, S.A. Litherland, D.C. Roopenian, and K.A. Iczkowski. 2007. Characterization of HKE2: an ancient antigen encoded in the major histocompatibility complex. Tissue Antigens. 69(2): 181-188.

4. Murawski, M.R., S.A. Litherland, M.J. Clare-Salzler, and A. Davoodi-Semiromi. 2006. Upregulation of Foxp3 expression in mouse and human Treg is IL-2/STAT5 dependent: implications for the NOD STAT5B mutation in diabetes. Ann NY Acad Sci. 1079: 198-204.

5. Xiang, Z., S.A. Litherland, N.B. Sorensen, B. Proneth, M.S. Wood, A.M. Shaw, W.J. Millard, and C. Haskell-Luevano. 2006. Pharmacological characterization of 40 human melanocortin receptor polymorphisms with the endogenous proopiomelanocortin derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry. 45(23): 7277-7288.

6. Proneth, B., Z. Xiang, I.D. Pogozheva, S.A. Litherland, O.S. Gorbatyuk, A.M. Shaw, W.J. Millard, H.I. Mosberg, and C. Haskell-Luevano. 2006. Molecular Mechanism of the Constitutive Activation of the L250Q Human Melanocortin-4 Receptor Polymorphism. Chemical Biology & Drug Design. 67(3): 215-229.

7. Litherland, S.A., K.M. Grebe, N.S. Belkin, E. Paek, J. Elf, M. Atkinson, L. Morel, M.J. Clare-Salzler, and M.J. McDuffie. 2005. Nonobese diabetic mouse congenic analysis reveals chromosome 11 locus contributing to diabetes susceptibility, macrophage STAT5 dysfunction, and GM-CSF overproduction. J Immunology. 175(7): 4561-4565, Oct 1.

8. Litherland, S.A., T.X. Xie, K.M. Grebe, A. Davoodi-Semiromi, J. Elf, N.S. Belkin, L.L. Moldawer, and M.J. Clare-Salzler. 2005. Signal Transduction Activator of Transcription 5 (STAT5) Proteins are Dysfunctional in Autoimmune Monocytes & Macrophages. J Autoimmunity. 24: 297-310.

9. Lian, W., S.A. Litherland, H. Badrane, W. Tan, D. Wu, H.V. Baker, P.A. Gulig, D.V. Lim, and S. Jin. 2004. Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles. Anal Biochem. 334: 134-144.

10. Dongqi, T., B. Burkhardt, L. Cao, K. Ahren, S. Litherland, M. Aktinson, and L. Yang. 2004. In vitro generation of functional insulin producing cells from human bone marrow-derived stem cells. Diabetes. 53(7): 1721-1732.

11. Litherland, S.A., T.X. Xie, Y. Li, K.M. Grebe, S. Reddy, L.L. Moldawer, H. Herschman, and M. J. Clare-Salzler. 2004. IL10 Resistant PGS2 Expression in NOD Mouse Macrophages and At-Risk/Type 1 Diabetic Human Monocytes. J Autoimmunity. 22(3): 227-233.

12. Peng, R., Y. LI, K. Brezner, S.A. Litherland, and M.J. Clare-Salzler. 2003. Abnormal Peripheral Blood Dendritic Cell Populations in Type 1 Diabetes. NY Acad of Sciences. 1005: 1-4.

13. Parkih, S.S., S.A. Litherland, M. Clare-Salzler, W. Li, P.A. Gulig, and F.S. Southwick. 2003. CapG^-/- Mice Have Specific Host Defense Defects That Render Them More Susceptible than CapG^+/+ Mice to Listeria monocytogenes Infection but Not to Salmonella enterica serovar. typhimurium Infection. Infection and Immunity. 71(11): 1-9.

14. Litherland, S.A., J.-X. She, D. Schatz, K. Fuller, A.D. Hutson, Y. Li, K. M. Grebe, D. S. Whittaker, K. Bahjat, D. Hopkins, Q. Fang, C. Wasserfall, R. Cook, M.A. Dennis, S. Crockett, J. Sleasman, J. Kocher, A. Muir, J. Silverstein, M. Atkinson, and M. J. Clare-Salzler. 2003. Aberrant Monocyte Prostaglandin Synthase 2 (PGS2) in Type 1 Diabetes Before & After Disease Onset. Pediatric Diabetes. 4: 10-18.

15. Litherland, S. A., T. Xie, A. Hutson, D. S. Whittaker, D. Schatz, A. Hofig, and M. Clare-Salzler. 1999. Aberrant Monocyte Prostaglandin Synthase 2 (PGS2) Expression Defines an Antigen Presenting Cell Defect and is a Novel Cellular Marker for Insulin Dependent Diabetes Mellitus (IDDM). Journal of Clinical Investigation 104: 515-523.

16. Litherland, S. A. (author, editor) (1993). SLSTP FLT 1993: An Introduction to Payload Development; Project Summary and Student Reports; NASA Life Sciences, KSC, FL.

17. Litherland, S. A. (1993). Biospecimen Sharing Program(BSP) : STS-56 PARE-03 Support Operations Summary LSSF, KSC; NASA Life Sciences, KSC, FL.

18. Litherland, S. A. (1993). Biospecimen Sharing Program(BSP) : STS-54 PARE-02 Support Operations Summary & Lessons Learned LSSF, KSC; NASA Life Sciences, KSC, FL.

19. Steffen, S. L., C. Simerly, R. Fiser, S. Litherland, and G. Schatten. (1991). Fertilization During Aircraft Parabolic Flight. ASGSB Bulletin. 5(1): October.

20. Litherland, S. A. (1991). Koi Water Acclimation Test Report; Spacelab-J support of L-2 Experiment; NASA Life Sciences, KSC, FL.

21. Litherland, S. A. (1990). Koi Water Compatibility Report; Spacelab-J support of L-2 Experiment; NASA Life Sciences, KSC, FL.

22. Litherland, S. A. (1990). Final Report for the 1990 Space Life Sciences Training Program (SLSTP'90): The SLSTP'90/SURF Collaboration and Student Introduction to Flight Support; NASA Life Sciences, KSC, FL.

23. Litherland, S. A. (1990). "Part 5: Sea Urchin Fertilization Flight Project." Chapter in The 1990 NASA Space Life Sciences Training Program Curriculum Workbook. R. Biro, ed. p.79-98; NASA Life Sciences, KSC, FL.

24. Gregory, J. F., III, and S. A. Litherland. (1986). Efficacy of the rat bioassay for the determination of biologically available vitamin B-6. Journal of Nutrition. 116: 87-97.

25. Nguyen, L. B., M. E. Hiner, S. A. Litherland and J. F. Gregory III. (1983). Relative biological activity of nonphosphorylated vitamin B-6 compounds in the rat. Journal of Agricultural and Food Chemistry. 31: 1282-1287.

Publications in Submission

Rumore-Maton, B. *, J. Elf, N. Belkin, * B. Stutevoss, F. Seydel, E. Garrigan, and S. A. Litherland. M-CSF/GM-CSF Regulation of STAT5 Isoform is Disrupted in Nonobese Diabetic (NOD) Mice. 2007. In revised submission to Autoimmunity.

Seydel, F., E. Garrigan, B. Stutevoss, N. Belkin, *J. Shi, A. Davoodi-Semiromi, and S. A. Litherland. 2007. GM-CSF dysregulates STAT5 binding at non-coding regulatory regions associated Epigenetic Regulation of Csf2 and Ptgs2 gene expression in Nonobese Diabetic (NOD) Mouse Peritoneal and Bone Marrow Derived Macrophages. In revised submission to Journal of Immunology.

Davoodi-Semiromi, A., S.A. Litherland, C.-Q. Xia, E. Paek, * G. Ghaffari, M. A. Atkinson, and M. J. Clare-Salzler. 2005. CD25 is required for activation of long-form Stat5 in regulatory T cells. In revised submitted to the Journal of Immunology.

Belkin, N.S. * and S.A. Litherland. February 2005. PIAS3 & STAT5 Interactions Disrupted in Nonobese Diabetic (NOD) Mice. Submitted to the Journal of Undergraduate Research.

Manuscripts in Preparation

Garrigan, E., and S.A. Litherland. STAT proteins & Epigenetic Regulation of Gene Expression : The Missing Mechanistic Link between Environment & Genetic Risk for Autoimmunity? a review article.

Garrigan, E., F. Seydel, B. Stutevoss, N. Belkin, * M. Clare-Salzler, M. Atkinson, L. Yang, A.B. Peck, L. Morel, M. McDuffie, A. Davoodi-Semiromi, and S. A. Litherland. Nonobese Diabetic (NOD) Congenic Mouse Analysis Defines an Idd4.3 Sequence Crucial to GM-CSF Regulation of STAT5 Binding and Associated Epigenetic Changes at the Csf2 and Ptgs2 Regulatory Sequences in Macrophages.

Garrigan, E., B. Stutevoss, M. McDuffie, M. Clare-Salzler, A. Davoodi-Semiromi, and S. A. Litherland. GM-CSF overexpression, STAT5 phosphorylation and STAT5 binding at Idd4.3 Sequence Upstream of Csf2 is Differentially Regulated in Male and Female Nonobese Diabetic (NOD) Congenic Mouse Myeloid Cells.

Litherland, S.A., A. Zaytoun, M. Yang, N.S. Belkin, * J. Elf, T. Brusko, M. Aktinson, and T. Murphy. Immunological Characterization of Peripheral Blood Mononuclear Cells (PBMC) from Pediatric Patients with OCD, and/or Tics Relative to Exacerbation and Therapeutic Intervention with D2 Blocker, SSRI and Omega 3 Fatty Acid Treatments.

Belkin, N.S., *E. Garrigan, K. Pauley,* J. Elf, M. McDuffie, and S. A. Litherland. Loss of Regulation by PIAS3 Supports Persistent STAT5 Tyrosine Phosphorylation and Prevent STAT5 Sumolation in NOD Mouse Macrophages & Autoimmune Human Monocytes.

Abstracts

Wilson, K.R., B. Proneth, H. Luesch, C. Haskell-Luevano, and S.A. Litherland. 2007. Construction and Characterization of Melanocortin-2 and -4 Receptor Chimeras. American Peptide Society Symposium 2007.

Garrigan, E., F. Seydel, B. Stutevoss, N. Belkin, M. Clare-Salzler, M. Atkinson, L. Yang, A.B. Peck, L. Morel, M. McDuffie, A. Davoodi-Semiromi, and S. A. Litherland. Nonobese Diabetic (NOD) Congenic Mouse Analysis Defines an Idd4.3 Sequence Crucial to GM-CSF Regulation of STAT5 Binding and Associated Epigenetic Changes at the Csf2 and Ptgs2 Regulatory Sequences in Macrophages. Keystone Symposium; Jaks and STATs. Colorado Springs. Jan 2007 and UF COM Research Day Presentation: April 2007.

F. Seydel, E. Garrigan, K. Pauley, B. Stutevoss, N. Belkin, M. McDuffie, L. Yang, L. Morel, and S.A. Litherland. STAT5 DYSFUNCTION IN AUTOIMMUNE MYELOID CELLS 2006 Gene Expression and Signal Transduction in the Immune System, Cold Spring Harbor Laboratory meeting and UF COM Research Day Presentation; April 2006.

E. Garrigan, F. Seydel, K. Pauley, B. Stutevoss, N. Belkin, M. McDuffie, L. Morel, and S.A. Litherland. 2006. GM-CSF DYSREGULATION OF STAT5 IN AUTOIMMUNE MYELOID CELLS2006 Gene Expression and Signal Transduction in the Immune System, Cold Spring Harbor Laboratory meeting and UF COM Research Day Presentation;. April 2006.

Belkin, N.S., and S.A. Litherland. April 2005. PIAS3 & STAT5 Interactions Disrupted in Nonobese Diabetic (NOD) Mice. FASEB/AAI Experimental Biology Conference. San Diego, CA.

Xiang, Z. S.A. Litherland, and C. Haskell-Luevano. April 2005. In vitro pharmacological characterization of human melanocorin-4 receptor polymorphisms and cell surface expression. FASEB/Experimental Biology Conference. San Diego, CA.

Davoodi-Semiromi, A., E. Paek, C.Q. Xia, T. Barker, S.A. Litherland, and M.J. Clare-Salzler. April 2005. Activation of the long-form of STAT5 and upregulation of Foxp3 in regulatory CD4+ CD25+ T cells by IL-2. FASEB/AAI Experimental Biology Conference. San Diego, CA.

Belkin, N.S., and S.A. Litherland. April 2005.PIAS3 & STAT5 Interactions Disrupted in Nonobese Diabetic (NOD) Mice. College of Medicine Research Day Presentations.

J. Elf and N. Belkin, B. Rumore-Maton, M. J. Clare-Salzler, M. McDuffie, and S. A. Litherland. July 2004. Dysregulation of Signal Transduction Activators of Transcription 5 (STAT5) in Autoimmune Type 1 Diabetes (T1D). International FOCIS Meeting, Montreal, Canada. Awarded FOCIS Travel Award for oral & poster presentation.

S.A. Litherland, M. J. Clare-Salzler, and M. McDuffie. April-May 2004. GM-CSF, PGS2, & STAT5 Dysregulation in Autoimmune Monocytes and Macrophages. Cold Spring Harbor Meeting: Gene Expression & Signaling in the Immune System, CSH Laboratory, NY.

J. Elf and N. Belkin, B. Rumore-Maton, M. J. Clare-Salzler, M. McDuffie, and S. A. Litherland. May 2004. Dysregulation of Signal Transduction Activators of Transcription 5 (STAT5) in Autoimmune Type 1 Diabetes (T1D). College of Medicine Research Day, Gainesville, FL.

S. A. Litherland, B. Rumore-Maton, J. Elf, N. Belkin, M. J. Clare-Salzler, and M. McDuffie. April 2004. STAT5 Dysfunction in Autoimmune Monocytes and Macrophages. Keystone Symposia: Jaks and STATs, Whistler, British Columbia, Canada

Dongqi, T., B. Burkhardt, L. Cao, K. Ahren, S. Litherland, M. Aktinson, and L. Yang. June 2004. In vitro generation of functional insulin producing cells from human bone marrow-derived & Liver-derived stem cells. ADA annual meeting, Orlando, FL.

Litherland, S.A., J. Elf, E. Paek, M.J. Clare-Salzler, and M. McDuffie. Abstract for AAI Annual Meeting, Denver, Colorado. May 2003. Myeloid Cell GM-CSF, STAT5, and Prostaglandin Synthase 2 (PGS2/COX2) Expression in Nonobese Diabetic (NOD) Mice Myeloid Cell GM-CSF, STAT5, and Prostaglandin Synthase 2 (PGS2/COX2) Expression in Nonobese Diabetic (NOD) Mice. Awarded AAI Junior Faculty Travel Award.

Litherland, S.A., M. McDuffie, and M.J. Clare-Salzler. Abstract for NIH Workshop on Proteomics in Diabetes. April 2003. STAT5 Dysfunction in Type 1 Diabetes: A Role in Cytokine/Prostanoid Regulation of Myeloid Cell Differentiation & Activation?

Smith, L.E., C.L. Barnes, P.S. Quint, T. Brusko, S. Litherland & D.A. Ostrov. Abstract for NIH Workshop on Proteomics in Diabetes. April 2003. Structural Genomics and Proteomics of the Major Histocompatibility Complex.

Litherland, S.A., J. Elf, E. Paek, W. -K. Tse, R. Peng, K L. Womer, A. Davoodi-Semiromi, Y. Li, V. Dharnidharka, M.J. Clare-Salzler, L. Morel, and M. McDuffie. Abstract for UF College of Medicine Research Day. April 2003. STAT5 Dysfunction in Autoimmune Myeloid Cells Activation and Differentiation. Awarded Best Poster Presentation-Basic Sciences.

Quint, P.S., S.A. Litherland, and D.A. Ostrov. Abstract for UF College of Medicine Research Day. April 2003. Structural Genomics of the Major Histocompatibility Complex: Allograft Inflammatory Factor 1 (AIF-1).

Parikh, S. S., S.A. Litherland, M.J. Clare-Salzler, W. Li, P. A. Gulig, and F. S. Southwick. Abstract for UF College of Medicine Research Day. April 2003. Loss of the Actin Filament Capping Protein CapG Increases Susceptibility to Listeria monocytogenes, but not Salmonella typhimurium Infection.

Litherland, S.A., J. Elf, E. Paek, W. -K. Tse, R. Peng, K L. Womer, A. Davoodi-Semiromi, Y. Li, V. Dharnidharka, M.J. Clare-Salzler, L. Morel, and M. McDuffie. Abstract for Dendritic Cell Keystone Symposium. March 2003. STAT5 Dysfunction in Autoimmune Myeloid Cells Activation and Differentiation. Awarded Invitation for Workshop Oral Presentation.

Litherland, S.A., J. Elf, Y. Li, R.H. Peng, M. McDuffie, and M. J. Clare-Salzler. 2002. Abstract for Salk Institute Tyrosine Phosphorylation and Signal Transduction Meeting 2002. STAT5 Dysfunction
in Type 1 Diabetes : Persistent Tyrosine Phosphorylation, Aberrant DNA Binding, & Altered Subcellular Translocation During Myeloid Cell Differentiation

Parikh, S. S., S. A. Litherland, M.J. Clare-Salzler, W. Li, P. A. Gulig, and F. S. Southwick. 2002. ASH Abstract: Loss of the Actin Filament Capping Protein CapG Increases Susceptibility to Listeria monocytogenes, but not Salmonella typhimurium Infection.

Womer, K.L., A. Oberholzer, F.R. Bahjat, R. Ungaro, R.H. Peng, S. A. Litherland, D. LaFace, L.L. Moldawer, and M.J. Clare-Salzler. 2002. Abstract for ASN Annual Meeting. Adenovirus Induced Dendritic Cell Maturation Is Inhibited by IL-10 Expression: A Potential Therapeutic Approach to Regulation of Alloresponses.

Casp, C.B., S.A. Litherland, J. -X. She, W.T. McCormack. 2002. Antigen processing and presentation genes in Vitiligo susceptibility. FASEB J. 16(5): A1219.

Litherland, S.A., R.H. Peng, Y. Li, and M.J. Clare-Salzler. 2002. Abstract for Keystone Symposium/JAKs and STATs: Activation and Biologic Impact, January 2002 and for COM Research Day, April 2002: STAT5 Dysfunction, GM-CSF Hyper-Responsiveness, & Aberrant Monocyte/Macrophage Prostaglandin Synthase 2 Expression in Type 1 Diabetes.

Litherland, S.A., T.X. Xie, D.S. Whittaker, K. Bahjat, K.M. Grebe, L. Selvaraj, C. Wasserfall, A. B. Peck, L.L. Moldawer, and M. J. Clare-Salzler. 2001. Abstract for FASEB/Experimental Biology/AAI Annual Meeting, March 2001, Orlando, Florida and COM Research Day, March 2001: Type 1 Diabetic Monocyte Prostaglandin Synthase 2 Activity Impairs T cell Activation Induced Cell Death by Suppressing IL2 Signaling.

Litherland, S. A., A. Davoodi-Semironi, Y. Li, and M.J. Clare-Salzler. 2001. Abstract for January 2001 Keystone Symposium: Regulation of Immunity and Autoimmunity. Colorado and COM Research Day, March 2001: Dysfunctional GM-CSF-Mediated Transcriptional Regulation in Type 1 Diabetic & Pre-diabetic Human Monocytes & Nonobese Diabetic (NOD) Mouse Macrophages.

Litherland, S. A., T. Xie, A. Davoodi-Semironi, D. Schatz, and M. J. Clare-Salzler. 2000. Abstract for 2000 FASEB Summer Research Conference on Signal Transduction in the Immune System, Vermont: Prolonged GM-CSF Activation of STAT5 in Type 1 Diabetes: Possible Mechanism for Aberrant Prostaglandin Synthase 2 (PGS2) Expression by Autoimmune Monocytes & Macrophages.

Yoshida, H., M. Satoh, A. Mizutani, K.M. Behney, S.A. Litherland, M.J. Clare-Salzler, H.B. Richards, and W.H. Reeves. 2000. Abstract for the American College of Rheumatology 64th Annual Scientific Meeting, Philadelphia, PA: Malleability of Autoimmune Disease Phenotypes.

Litherland, S.A., T. Xie, A. Muir, D. Schatz, J.-X. She, M. Atkinson, and M.J. Clare-Salzler. 1999. Abstract for Immunology of Diabetes ’99 meeting, Italy: Prostaglandin Synthase 2 Expression as a Risk Assessment Tool for IDDM: A New Avenue for Prevention & Intervention?

Litherland, S. A., D.S. Whittaker, K.M. Grebe, M. McDuffie, L.L. Moldawer, D. Schatz, and M.J. Clare-Salzler. (1999). Abstract from Keystone Meeting March-April 1999: Autoimmunity & Tolerance. Dysregulation of Prostaglandin Synthase 2 (PGS2) in Autoimmunity: IL10 Resistance & STAT5 Regulation.

Litherland, S.A., T. X. Xie, D. S. Whittaker, L. L Moldawer, and M. J. Clare-Salzler. (1998). Presentation Abstract from Immunology of Diabetes '98 meeting, Chicago, Illinois: Aberrant Monocyte Prostaglandin Synthase 2 (PGS2) Expression Inhibits IL2 and IL2 Receptor (CD25) Expression in IDDM T-cells. Autoimmunity. 24: Abstracts.

Litherland, S.A., T. X. Xie, D. S. Whittaker, A. D. Hutson, D. Schatz, L. L Moldawer, and M. J. Clare-Salzler. (1998). Abstract from Immunology of Diabetes '98 meeting, Chicago, Illinois: Aberrant Monocyte Prostaglandin Synthase 2 (PGS2) Expression: A Novel Cellular Marker for IDDM Risk. Autoimmunity.24: Abstracts.

Litherland, S.A., A. Hofig, T. Xie, D. Schatz, N. Maclaren, and M. Clare-Salzler. (1996). Presentation Abstract from Immunology of Diabetes '96 meeting, Canberra, Australia: Individuals at Risk for IDDM Constitutively Express Prostaglandin Synthase 2 (PGS2) in the Absence of Monocyte Activation. Autoimmunity 22(12): Abstracts.

Litherland, S., T. Xie, A. Hofig, J. Anderson, C. Robinson, and M. Clare-Salzler. (1995). Abstract from Immunology of Diabetes'95 meeting, Rome, Italy: Characterization of Suppression Activity Derived from Regulatory Cells of the NOD Pancreatic Lymph Node. Autoimmunity. 21(1): 29.

Fascullo, M. T., S. Litherland, R. Rothstein, and W. K. Holloman. (1987). Partial purification of a DNA reannealing activity from meiotic extracts of Saccharomyces cerevisiae. Abstract from Yeast Genetics and Molecular Biology, San Francisco June 1987 meeting.

7/12/07 sal

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