Maureen M. Goodenow, Ph.D.
Professor, Unit Co-Director, Experimental Pathology
Department of Pathology, Immunology and Laboratory Medicine
University of Florida College of Medicine
Gainesville, Florida

Publications
Refereed Publications-Journal articles:
    1. Plata, F., M.M. Goodenow and F. Lilly. Studies of cloned Friend erythroleukemia tumor cells.  Modulation of the tumor-specific cytolytic T lymphocyte response by infectious Friend virus production in vitro.  J. Exp. Med. 151:726-742, 1980.
    2. Goodenow, M.M. and F. Lilly. Expression of differentiation and murine leukemia virus antigens on cells of primary tumors and cell lines derived from chemically induced lymphomas of RF/J mice. Proc.Natl.Acad.Sci.USA 81:7612-7616, 1984.
    3. Shih, C.-K., M. Linial, M.M. Goodenow and W.S. Hayward.  Nucleotide sequence 5' of the chicken c-myc coding region:  localization of a non-coding exon that is absent from myc  transcripts in most ALV-induced lymphomas.  Proc. Natl. Acad. Sci. USA 81:4697-4701, 1984.
    4. Chinsky, J., M.M. Goodenow, M. Jackson, F. Lilly, L. Leinwand and G. Childs.  Comparison of endogenous murine leukemia virus proviral organization and RNA expression in RF and AKR mice.  J. Virol. 53:94-99, 1985.
    5. Goodenow, M.M., K. Kessler, L. Leinwand and F. Lilly.  Absence of trisomy 15 in chemically induced murine T-cell lymphomas.  Cancer Genet. Cytogenet.  19:205-211, 1986.
    6. Goodenow, M.M. and W.S. Hayward.  5' long terminal repeats of myc- associated proviruses appear structurally intact but are functionally impaired in tumors induced by avian leukosis viruses.  J. Virol. 61:2489-2498, 1987.
    7. Goodenow, M., T. Huet, W. Saurin, S. Kwok, J. Sninsky, and S. Wain-Hobson. HIV-1 isolates are rapidly evolving quasispecies: evidence for viral mixtures and preferred nucleotide substitutions. J.Acquir.Immune Defic.Syndr. 2:344-352, 1989.
    8. Plata, F., F. Garcia-Pons, A. Ryter, F. Lebargie, M.M. Goodenow, M.H. Quan Dat, B. Autran, and C. Mayaud.  HIV-1 infection of lung alveolar fibroblasts and macrophages in humans.  AIDS Res. and Human Retroviruses 6:979-986, 1990. 
    9. Farmerie, W.G., M.M. Goodenow, and B.M. Dunn.  Cloning, expression and kinetic characterization of the feline immunodeficiency virus proteinase. Adv Exp Med Biol. 306:511-513, 1991.
    10. Grimes, H.L., B.E. Szente, and M.M. Goodenow.  C-ski cDNAs are encoded by eight exons, six of which are closely linked in the chicken genome.  Nuc. Acids Res. 20:151-156, 1992.
    11. Bottazzi, M.E., M.M. Goodenow, M.G. Moscovici, and C. Moscovici.  BM2L is a spontaneous leukemogenic variant of a non-leukemogenic v-myb transformed myeloid cell line.  Oncogene 8:731-736, 1993.
    12. Lamers, S.L., J.W. Sleasman, K.A. Barrie, S.M. Pomeroy, D.J. Barrett, and M.M. Goodenow.  Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivo.  J. Virol. 67:3951-3960, 1993.
    13. Grimes, H.L., M.R. Ambrose, and M.M. Goodenow.  C-ski transcripts with and without exon 2 are expressed in skeletal muscle and throughout chick embryogenesis. Oncogene 8:2863-2868, 1993. 
    14. Lamers, S.L., J.W. Sleasman, K.A. Barrie, S.M. Pomeroy, D.J. Barrett, and M.M. Goodenow.  Persistence of multiple maternal HIV-1 genotypes in infants infected by perinatal transmission. J. Clin. Invest. 93:380-390, 1994. 
    15. Sleasman, J.W., T.O. Harville, G.B. White, J. George, D.J. Barrett, and M.M. Goodenow.  Arrested rearrangement of T cell receptor V-beta genes in thymocytes from children with X-linked severe combined immunodeficiency disease.  J. Immunol. 153:442-448, 1994.
    16. Bhatt, D., L. Zhang, A. Gustchina, L. Reshetnikova, A. Wlodawer, W. Farmerie, M.M. Goodenow and B. M. Dunn. Structure and enzymolodgy of FIV and HIV Proteases: relation to the development of AIDS drug resistance. Protein Science 4, 2:91-98, 1995.
    17. Wlodawer, A., A. Gustchina, L. Reshetnikova, J. Lubkowski, A. Zdanov, K.Y. Hui, E.L. Angleton, W.G. Farmerie, M.M. Goodenow, D. Bhatt, and B.M. Dunn.  Crystal structure of an inhibitor complex of the protease from feline immunodeficiency virus. Nature Struct. Biol. 2:480-488, 1995.
    18. Ambrose, M.R., M.E. Bottazzi, and M.M. Goodenow. Expression of the c-ski proto-oncogene during cell cycle arrest and myogenic differentiation.  DNA Cell Bio. 14:701-707, 1995.
    19. Aleixo, L., M.M. Goodenow, and J.W. Sleasman.  Highly enriched populations of T cell depleted monocytes verified by molecular analysis.  Clin. Diagnostic Lab. Immunol. 2:733-739, 1995. 
    20. Barrie, K.A., E. Perez, S.L. Lamers, J.W. Sleasman, B.M. Dunn, and M.M. Goodenow.  Natural variation in HIV-1 protease, Gag p7 and p6, and protease cleavage sites within Gag/Pol polyproteins: amino acid substitutions in the absence of protease inhibitors in mothers and children infected by human immunodeficiency virus type 1.  Virology  219:407-416, 1996.
    21. Lamers, S.L., J.W. Sleasman, and M.M. Goodenow.  A model for alignment of V1 and V2 hypervariable domains of Env gp120 in human immunodeficiency virus type 1 (HIV-1): Positions of charged amino acids are conserved.  AIDS Res. Human Retroviruses  12:1169-1178, 1996.
    22. Sleasman, J.W., L.F. Aleixo, A. Morrow, S. Skoda-Smith, and M.M. Goodenow. CD4+ memory T cells are the predominant population of HIV-1 infected lymphocytes in neonates and children.  AIDS 10:1477-1484, 1996.
    23. Aleixo, L., M.M. Goodenow, and J.W. Sleasman.  Zidovudine administered to HIV-1 infected women and their neonates reduces pediatric infection independent of an effect on levels of maternal virus.  J. Pediatr. 130:906-914,1997.
    24. Sleasman, J.W., B.H.Leon, L.F. Aleixo, M. Rojas, and M.M. Goodenow.  Immunomagnetic selection of purified monocyte and lymphocyte populations from peripheral blood mononuclear cells following cryopreservation. Clin. Diagnostic Lab. Immunol. 4:653-658,1997.
    25. Massengill, S.M., M.M. Goodenow, and J.W. Sleasman.  SLE nephritis is associated with an oligoclonal expansion of intrarenal T cells. Am J Kidney Dis. 31:418-426, 1998. 
    26. Krebs, F.C., D. Mehrens, S. Pomeroy, M.M. Goodenow, and B. Wigdahl.  Human immunodeficiency virus type 1  long terminal repeat quasispecies differ in basal transcription and nuclear factor requirement in human glial cells and lymphocytes. J. Biomed. Sci .5:31-44, 1998.
    27. Bloom G., E. Perez, S. Parikh, J. Kay, J. Mills, M. Goodenow, B.M. Dunn. A comparison of gag-pol precursor cleavage in naturally arising HIV variants.  Adv. Exp. Med. Biol. 436:53-57, 1998.
    28. Tuttle, D.L., J.K. Harrison, C.B. Anders,  J.W. Sleasman, and M.M. Goodenow.  Expression of CCR5 increases during monocyte differentiation and directly mediates macrophage susceptibility to infection by human immunodeficiency virus type 1.  J. Virol. 72:4962-4969, 1998. 
    29. Skinner, L.T., S.L. Lamers, M.M. Goodenow, and M. Katzman. Analysis of a large collection of natural HIV-1 integrase sequences, including those from long-term non-progressors.  J.A.I.D.S. Human Retovirol. 19:99-110, 1998.
    30. Zeichner, S.L., P. Palumbo, Y.Feng, X. Xiao, D. Gee, J. Sleasman, M.M. Goodenow, R. Biggar, and D. Dimitrov.  Rapid telomere shortening in children. Blood 93:1-8, 1999.
    31. Sleasman, J.W., R.P. Nelson, M.M. Goodenow, D. Wilfert, A. Hutson, M. Baseler, J. Zuckerman, P.A. Pizzo, and B.U. Mueller.  Immunoreconstitution following ritonavir therapy in HIV-infected children involves multiple lymphocyte lineages. J. Peds. 134:597-606, 1999.
    32. B. Burkhardt, D. Kephart, C. Coberley, J. Sleasman, and M. Goodenow.  Postmortem isolation and analysis of human genomic DNA and HIV-infected tissues: a molecular diagnostics application.  Promega Notes 71:30-31, 1999.
    33. Ping, L-H., J. Nelson, I.F. Hoffman, J. Schock, S.L. Lamers, M. Goodman, P. Vernazza, P. Kazembe, M. Maida, D. Zimba, M.M. Goodenow, S.A. Fiscus, M.S. Cohen, and R. Swanstrom.  Characterization of V3 sequence heterogeneity in subtype C HIV-1 isolates from Malawi: underrepresentation of X4 variants.  J. Virol.73:6271-6281, 1999. 
    34. Acquino de Jesus, M.J., C. Anders, G. Miller, J.W. Sleasman, M.M. Goodenow, and W.A. Andiman. Genetically and epidemiologically related Anon-syncytium-inducing@ isolates of HIV-1 display heterogeneous growth patterns in macrophages. J.Med.Virol. 61: 171-180, 2000. 
    35. Kouba, J.K., B.R. Burkhardt, I.M. Alavarez, M.M. Goodenow, and W.C. Buhi. Oviductal plasminogen activator inhibitor-1 [PAI-1]: mRNA, protein, and hormonal regulation during the estrous cycle and early pregnancy in the pig. Mol. Reprod. Develop. 56:378-386, 2000. 
    36. Lathey, J.L., D. Brambilla, M.M. Goodenow, M. Nokta, S. Rasheed, E.B. Siwak, J.W. Bremer, D.D. Huang, Y. Yi, P.S. Reichelderfer, and R.G. Collman for the Macrophage Tropic Viral Kinetic Team [MTVK], PACTG, NIAID. Co-receptor usage was more predictive than NSI/SI phenotype for HIV replication in macrophages: Is NSI/SI phenotyping sufficient? J. Leuk. Biol. 68:324-330, 2000.  
    37. Kou, Z., J. Puhr, M. Rojas, W.T.McCormack, M.M.Goodenow, and J.W. Sleasman. T cell receptor V? repertoire CDR3 length diversity differs within CD45RA and CD45RO T cell subsets in healthy and HIV-infected children. Clin.Diag.Lab.Immunol. 7:953-959, 2000. 
    38. Briggs, D.R., D.L.Tuttle, J.W. Sleasman, and M.M. Goodenow. Envelope V3 amino acid sequence predicts HIV-1 phemotype [coreceptor usage and tropism for macrophages]. AIDS 14:2937-2940, 2000. 
    39. David ,S.A., M.S. Smith, G.J. Lopez, I. Adany, S. Mukherjee, S. Buch, M.M. Goodenow, and O. Narayan. Selective transmission of R5-tropic HIV type 1 from dendritic cells to resting CD4+ T cells. AIDS Res Hum Retroviruses 17:59-68, 2001. 
    40. Perez, E.E., S.L. Rose, B. Peyser, S.L. Lamers, B. Burkhardt, B.M. Dunn, A.D. Hutson, J.W. Sleasman, and M.M. Goodenow. HIV-1 protease genotype predicts immune and viral response to combination therapy with protease inhibitors [PI] in PI-naïve patients. J. Inf. Dis., 183:579-588, 2001. 
    41. Mergia, A., S. Chari, D.L.Kolson, M.M. Goodenow, and T. Ciccarone. The efficiency of simian foamy virus vector type-1 (SFV-1) in non-dividing cells and in human PBLs. Virology 280:243-52, 2001. 
    42. Gaffari,G., D.J. Passalacqua, B.S. Bender, D.J. Briggs, M.M. Goodenow, and J.W. Sleasman. Human lymphocyte proliferation responses following primary immunization using rabies vaccine as a neoantigen. Clin. Diag. Lab. Imunol. 8:880-883, 2001. 
    43. Goodenow, M.M., G. Bloom, S.L. Rose, S.M. Pomeroy, P.O. O'Brien, E.E. Perez, J.W. Sleasman, and B.M. Dunn. Naturally occurring amino acid polymorphisms in human immunodeficiency virus type 1 (HIV-1) Gag NC p7 and the C-cleavage site impact GagPol processing by HIV-1 protease. Virology 292:137-149, 2002. 
    44. Tuttle, D.L., C.B. Anders, M.J.Acquino-deJesus, P.P. Poole, S.L. Lamers, D.R. Briggs, S.M. Pomeroy, L. Alexander, K.W.C. Peden, W.A. Andiman, J.W. Sleasman, and M.M. Goodenow. Increased replication by nonsyncytium-inducing HIV-1 isolates in monocyte-derived macrohpages is linked to clinical decline in patients. AIDS Res Hum Retroviruses, in press, 2002. 

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      BOOK CHAPTERS AND REVIEWS (invited)
       

    45. Goodenow, M.M., C.-K. Shih,  K.G. Wiman, and W.S. Hayward.  Oncogenic alterations of c-myc by avian leukosis viruses.  In Human T-Cell Leukemia-Lymphoma Viruses.  R.C. Gallo, M.E. Essex and L. Gross, eds.  Cold Spring Harbor Laboratory, New York, pp. 75-84, 1984.
    46. Wiman, K.G., C.-K. Shih, M.M. Goodenow, A.C. Hayday, H. Saito, S. Tonegawa, and W.S. Hayward.  Activation of the c-myc gene in avian and human B-cell lymphomas.  In Cancer Cell 2: Oncogenes and Viral Genes, Cold Spring Harbor Laboratory, New York, pp. 189-193, 1984.
    47. Wain-Hobson, S., M.M. Goodenow, T. Huet, S. Kwok, and J. Sninsky. HIV viruses are rapidly evolving quasispecies.  In Retroviruses of Humans A.I.D.S. and Related Animal Diseases. M. Girard and L. Valette, eds. Pasteur Vaccins, Paris. pp. 18-19, 1989.
    48. Farmerie, W.G., M.M. Goodenow, and B.M. Dunn.  Cloning, expression, and kinetic characterization of the feline immunodeficiency virus proteinase.  In Aspartic Proteinases:  Genetics, Structures, and Mechanisms.  Ben M. Dunn, ed. Plenum Press, New York. Advances in Experimental Medicine and Biology 306:511-513, 1991. 
    49. Sleasman, J.W. and M.M. Goodenow.  Pathogenesis and natural history of HIV infection. In Journal of the Florida Medical Association, 78:678-681, 1991.
    50. Goodenow, M.M., J.W. Sleasman, and S.L. Lamers.  Persistence of multiple maternal genotypes in infants infected by perinatal transmission.  In Vaccines 93. Modern Approaches to New Vaccines including Prevention of AIDS. H.S. Ginsberg, F. Brown, R.M. Chanock, and R.A. Lerner, eds. Cold Spring Harbor Laboratory Press, New York, 1993. pp. 125-129.
    51. Tillman, M., F.C. Krebs, R. Hinkel, S.M. Pomeroy, M.M. Goodenow, and B. Wigdahl.  Neuroglial-specific factors and the regulation of retrovirus transcription.  Adv. Neuroimmunol. 4:305-318, 1994.
    52. Sleasman, J.W. and M.M Goodenow.  HIV-1 infection: Pathogenesis and natural history.  In Clinical Manual on HIV and AIDS. J.W. Shands and D.L. Seckinger, eds. Florida Medical Association, Inc., Jacksonville. pp. 1-6, 1995.
    53. Krebs, F.C., M.M. Goodenow, and B. Wigdahl.  Neuroglial ATF/CREB factors interact with the human immunodeficiency virus type 1 long terminal repeat.  J. Neurovirol. 3 [Supp.1]: S28-S32,1997.
    54. Sleasman, J.W. and M.M. Goodenow.  Human Immunodeficiency Virus and Acquired Immune Deficiency (AIDS).  In Textbook of Molecular Medicine.  J.L. Jameson, ed. Humana Press, Inc. New York, NY. 1998.
    55. Sei, S.S. and M.M. Goodenow.  HIV-1 Neuropathogenesis.  In Human Immunodeficiency Virus: Biology, Immunology, and Molecular Biology. N. Saksena, ed.  Medical Systems SpA, Italy. Pp. 227-266, 1998.
    56. Sleasman, J.W., D.Tuttle, and M.M.Goodenow. HIV Infection and Acquired Immune Deficiency (AIDS): Pathogenesis and Natural History.  In Clinical Manual on HIV and AIDS.  J.W.Shands and D.L.Seckinger, eds. Florida Medical Association, Inc., Jacksonville, FL.  In press. 1999.
    57. M.M. Goodenow, Perez, E.E., and  J.W. Sleasman. Genetic variability in HIV-1 in children treated by protease inhibitors.  In Human Retroviral Infection: Immunological and Molecular Theories.  H. Friedman, K. Ugen, and M. Bendinelli, eds., Plenum Publishing Corporation, New York, NY.  Pp.287-305, 2000.
    58. Dunn, B.M., M.M. Goodenow, A. Gustchina, and A. Wlodawer. The family of retroviral proteases. Genome Biology 2002 3: reviews3006.1-3006.7. http://genomebiology.com/2002/3/4/reviews/3006.
    59. Sleasman, J.W. and M.M. Goodenow. HIV-1 infection. Journal of Allergy and Clinical Immunology. In press.

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